WFRF:(Sommer Wolfgang H)
Sökning: WFRF:(Sommer Wolfgang H) > β-Arrestin 2 knocko...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04390naa a2200469 4500 | |
| 001 | oai:DiVA.org:liu-94653 | |
| 003 | SwePub | |
| 008 | 130628s2013 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:127776655 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-946532 URI |
| 024 | 7 | a https://doi.org/10.1007/s00213-013-3166-x2 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1277766552 URI |
| 040 | a (SwePub)liud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Björk, Karlu Karolinska Institutet4 aut |
| 245 | 1 0 | a β-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol |
| 264 | c 2013-06-19 | |
| 264 | 1 | b Springer,c 2013 |
| 338 | a print2 rdacarrier | |
| 520 | a RationaleThe rewarding effects of alcohol have been attributed to interactions between opioid and dopaminergic system within the mesolimbic reward pathway. We have previously shown that ablation of β-arrestin 2 (Arrb2), a crucial regulator of μ-opioid receptor function, attenuates alcohol-induced hyperlocomotion and c-fos activation in the nucleus accumbens.ObjectivesHere, we further investigated the role of Arrb2 in modulating alcohol-induced dopamine (DA) release and conditioned place preference (CPP). We also assessed the functional importance of Arrb2 for μ-opioid receptor surface expression and signaling following an acute alcohol challenge.MethodsAlcohol-evoked (0.375, 0.75, and 1.5 g/kg intraperitoneally) DA release was measured by in vivo microdialysis in the shell of nucleus accumbens. Reward was assessed by the CPP paradigm. Receptor function was assessed by μ-receptor binding and [35S]GTP-γ-S autoradiography.ResultsIn Arrb2 knockout mice accumbal DA levels reach maximum response at a lower dose compared to wild-type (wt) animals. In line with these results, Arrb2 knockout mice display increased CPP for alcohol as compared to wt mice. Finally, Arrb2 mutant mice display increased μ-opioid receptor signaling in the ventral and dorsal striatum and amygdala in response to a low dose of alcohol, indicating impaired desensitization mechanisms in these mice.ConclusionsOur results show that Arrb2 modulates the response to low doses of alcohol on various levels including μ-opioid receptor signaling, DA release, and reward. They also reveal a clear dissociation between the effects of Arrb2 on psychomotor and reward behaviors. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a arrestin | |
| 653 | a conditioned place preference | |
| 653 | a dopamine | |
| 653 | a reward | |
| 700 | 1 | a Tronci, Valeriau Psychobiology Section, NIDA, National Institutes of Health, Baltimore, MD, USA4 aut |
| 700 | 1 | a Thorsell, Annikau Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Centrum för social och affektiv neurovetenskap (CSAN)4 aut0 (Swepub:liu)annth96 |
| 700 | 1 | a Tanda, Gianluigiu Psychobiology Section, NIDA, National Institutes of Health, Baltimore, MD, USA4 aut |
| 700 | 1 | a Hirth, Natalieu University of Heidelberg, Mannheim, Germany4 aut |
| 700 | 1 | a Heilig, Markusu Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA4 aut0 (Swepub:liu)marhe41 |
| 700 | 1 | a Hansson, Anita C.u Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA4 aut |
| 700 | 1 | a Sommer, Wolfgang Hu Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD, USA4 aut |
| 710 | 2 | a Karolinska Institutetb Psychobiology Section, NIDA, National Institutes of Health, Baltimore, MD, USA4 org |
| 773 | 0 | t Psychopharmacologyd : Springerg 230:3, s. 439-449q 230:3<439-449x 0033-3158x 1432-2072 |
| 856 | 4 | u https://europepmc.org/articles/pmc3817962?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-94653 |
| 856 | 4 8 | u https://doi.org/10.1007/s00213-013-3166-x |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:127776655 |
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