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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003304naa a2200349 4500
001oai:DiVA.org:umu-66634
003SwePub
008130226s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-666342 URI
0247 a https://doi.org/10.3945/ajcn.111.0322682 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Strand, Tor A.4 aut
2451 0a Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age
264 1b Elsevier BV,c 2013
338 a print2 rdacarrier
520 a Background: Micronutrient deficiencies can affect cognitive function. Many young children in low-and middle-income countries have inadequate cobalamin (vitamin B-12) status. Objective: The objective was to measure the association of plasma concentrations of folate, cobalamin, total homocysteine, and methylmalonic acid with cognitive performance at 2 occasions, 4 mo apart, in North Indian children aged 12-18 mo. Design: Bayley Scales of Infant Development II were used to assess cognition. In multiple regression models adjusted for several potential confounders, we measured the association between biomarkers for folate and cobalamin status and psychomotor or mental development scores on the day of blood sampling and 4 mo thereafter. Results: Each 2-fold increment in plasma cobalamin concentration was associated with a significant increment in the mental development index score of 1.3 (95% CI: 0.2, 2.4; P = 0.021). Furthermore, each 2-fold increment in homocysteine or methylmalonic acid concentration was associated with a decrement in mental development index score of 2.0 (95% CI: 0.5, 3.4; P = 0.007) or 1.1 (95% CI: 0.3, 1.8; P = 0.004) points, respectively. Plasma folate concentration was significantly and independently associated with mental development index scores only when children with poor cobalamin status were excluded, ie, in those who had cobalamin concentrations below the 25th percentile. None of these markers was associated with psychomotor scores in the multiple regression models. Conclusions: Cobalamin and folate status showed a statistically significant association with cognitive performance. Given the high prevalence of deficiencies in these nutrients, folate and cobalamin supplementation trials are required to measure any beneficial effect on cognition. The study was registered at www.clinicaltrials.gov under the identifier number NCT00272116. Am J Clin Nutr 2013;97:310-7.
7001 a Taneja, Sunita4 aut
7001 a Ueland, Per M.4 aut
7001 a Refsum, Helga4 aut
7001 a Bahl, Rajiv4 aut
7001 a Schneede, Jörnu Umeå universitet,Klinisk farmakologi4 aut0 (Swepub:umu)josc0012
7001 a Sommerfelt, Halvor4 aut
7001 a Bhandari, Nita4 aut
7102 a Umeå universitetb Klinisk farmakologi4 org
7730 t American Journal of Clinical Nutritiond : Elsevier BVg 97:2, s. 310-317q 97:2<310-317x 0002-9165x 1938-3207
8564 u https://academic.oup.com/ajcn/article-pdf/97/2/310/23818498/310.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66634
8564 8u https://doi.org/10.3945/ajcn.111.032268

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