Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium

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Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium

Divaris, K. (författare): Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States,Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Haworth, S. (författare): Medical Research Council Integrative Epidemiology United, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Bristol Dental School, University of Bristol, Bristol, United Kingdom

Shaffer, J.R. (författare): Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, PA, Pittsburgh, United States

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Anttonen, V. (författare): Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland

Jönsson, Daniel (författare): Malmö University,Lund University,Lunds universitet,Malmö universitet,Odontologiska fakulteten (OD),Public Dental Service of Skåne, Lund, Sweden; Hypertension and Cardiovascular Disease, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden,University of North Carolina,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Swedish Public Dental Care of Skåne

Furuichi, Y. (författare): Division of Endodontology and Periodontology, Department of Oral Rehabilitation, Graduate School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan

Holtfreter, B. (författare): Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany,University Hospital Greifswald

Jönsson, D. (författare): Public Dental Service of Skåne, Lund, Sweden; Hypertension and Cardiovascular Disease, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden; Faculty of Odontology, Malmö University, Malmö, Sweden

Kocher, T. (författare): Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany,University Hospital Greifswald

Levy, S.M. (författare): Department of Preventive and Community Dentistry, College of Dentistry, University of Iowa, IA, Iowa City, United States

Magnusson, P.K.E. (författare): Karolinska Institutet,Karolinska Institute

McNeil, D.W. (författare): Center for Oral Health Research in Appalachia, NY, Appalachia, United States; Department of Psychology, West Virginia University, WV, Morgantown, United States; Department of Dental Public Health & Professional Practice, West Virginia University, WV, Morgantown, United States,Center for Oral Health Research in Appalachia, Appalachia, NY, USA; Department of Psychology, West Virginia University, Morgantown, WV, USA; Department of Dental Public Health & Professional Practice, West Virginia University, Morgantown, WV, USA

Michaëlsson, Karl, 1959- (författare): Uppsala University,Uppsala universitet,Medicinsk epidemiologi

North, K.E. (författare): Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Carolina Population Center, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States,Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Palotie, U. (författare): Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Papapanou, P.N. (författare): Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, Columbia University, College of Dental Medicine, NY, New York, United States,Division of Periodontics, Section of Oral, Diagnostic and Rehabilitation Sciences, Columbia University, College of Dental Medicine, New York, NY, USA

Pussinen, P.J. (författare): Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; nstitute of Dentistry, School on Medicine, University of Eastern Finland, Kuopio, Finland

Porteous, D. (författare): Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom

Reis, K. (författare): Institute of Genomics, University of Tartu, Tartu, Estonia

Salminen, A. (författare): Institute of Dentistry, School on Medicine, University of Eastern Finland, Kuopio, Finland; Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland; Public Health Evaluation and Projection Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland,Department of Periodontology, Oral Medicine and Oral Surgery, Institute for Dental and Craniofacial Sciences, Charité-Universitätsmedizin Berlin, Berlin, Germany,Charité - University Medicine Berlin

Schaefer, A.S. (författare): Department of Periodontology, Oral Medicine and Oral Surgery, Institute for Dental and Craniofacial Sciences, Charité–Universitätsmedizin Berlin, Berlin, Germany

Sudo, T. (författare): Institute of Education, Tokyo Medical and Dental University, Tokyo, Japan

Sun, Y.Q. (författare): Center for Oral Health Services and Research Mid-Norway (TkMidt), Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway

Suominen, A.L. (författare): Institute of Dentistry, School on Medicine, University of Eastern Finland, Kuopio, Finland; Institute of Dentistry, School on Medicine, University of Eastern Finland, Kuopio, Finland; Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland; Public Health Evaluation and Projection Unit, Finnish Institute for Health and Welfare (THL), Helsinki, Finland

Tamahara, T. (författare): Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan

Weinberg, S.M. (författare): Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, PA, Pittsburgh, United States

Lundberg, Pernilla, 1965- (författare): Umeå University,Umeå universitet,Institutionen för odontologi,Department of Odontology, Section of Molecular Periodontology, Umeå University, Umeå, Sweden

Marazita, M.L. (författare): Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, PA, Pittsburgh, United States

Johansson, Ingegerd (författare): Umeå University,Umeå universitet,Institutionen för odontologi,Department of Odontology, Section of Cariology, Umeå University, Umeå, Sweden

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Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (creator_code:org_t)

2022-08-24
2022
Engelska.
Ingår i: Journal of Dental Research. - : Sage Publications. - 0022-0345 .- 1544-0591. ; 101:11, s. 1408-1416

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying the relevant risk loci and understanding their molecular biology could highlight new prevention and management avenues. Our current understanding of oral health genomics suggests that dental caries and periodontitis are polygenic diseases, and very large sample sizes and informative phenotypic measures are required to discover signals and adequately map associations across the human genome. In this article, we introduce the second wave of the Gene-Lifestyle Interactions and Dental Endpoints consortium (GLIDE2) and discuss relevant data analytics challenges, opportunities, and applications. In this phase, the consortium comprises a diverse, multiethnic sample of over 700,000 participants from 21 studies contributing clinical data on dental caries experience and periodontitis. We outline the methodological challenges of combining data from heterogeneous populations, as well as the data reduction problem in resolving detailed clinical examination records into tractable phenotypes, and describe a strategy that addresses this. Specifically, we propose a 3-tiered phenotyping approach aimed at leveraging both the large sample size in the consortium and the detailed clinical information available in some studies, wherein binary, severity-encompassing, and “precision,” data-driven clinical traits are employed. As an illustration of the use of data-driven traits across multiple cohorts, we present an application of dental caries experience data harmonization in 8 participating studies (N = 55,143) using previously developed permanent dentition tooth surface–level dental caries pattern traits. We demonstrate that these clinical patterns are transferable across multiple cohorts, have similar relative contributions within each study, and thus are prime targets for genetic interrogation in the expanded and diverse multiethnic sample of GLIDE2. We anticipate that results from GLIDE2 will decisively advance the knowledge base of mechanisms at play in oral, dental, and craniofacial health and disease and further catalyze international collaboration and data and resource sharing in genomics research.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

data sciences
dental caries
dentition
permanent
epidemiology
Genetics
genome-wide association study
data sciences
dental caries
dentition, permanent
epidemiology
Genetics
genome-wide association study

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