Sökning: WFRF:(Tate Christian) > Predictors of Epile...
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000 | 06163naa a2200961 4500 | |
001 | oai:DiVA.org:uu-380937 | |
003 | SwePub | |
008 | 190402s2019 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/278943 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3809372 URI |
024 | 7 | a https://doi.org/10.1093/neuros/nyz0632 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/2789432 URI |
040 | a (SwePub)uud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Zanello, Marc4 aut |
245 | 1 0 | a Predictors of Epileptic Seizures and Ability to Work in Supratentorial Cavernous Angioma Located Within Eloquent Brain Areas |
264 | c 2019-10 | |
264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2019 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: The postoperative outcomes and the predictors of seizure control are poorly studied for supratentorial cavernous angiomas (CA) within or close to the eloquent brain area.OBJECTIVE: To assess the predictors of preoperative seizure control, postoperative seizure control, and postoperative ability to work, and the safety of the surgery.METHODS: Multicenter international retrospective cohort analysis of adult patients benefitting from a functional-based surgical resection with intraoperative functional brain mapping for a supratentorial CA within or close to eloquent brain areas.RESULTS: A total of 109 patients (66.1% women; mean age 38.4 ± 12.5 yr), were studied. Age >38 yr (odds ratio [OR], 7.33; 95% confidence interval [CI], 1.53-35.19; P = .013) and time to surgery > 12 mo (OR, 18.21; 95% CI, 1.11-296.55; P = .042) are independent predictors of uncontrolled seizures at the time of surgery. Focal deficit (OR, 10.25; 95% CI, 3.16-33.28; P < .001) is an independent predictor of inability to work at the time of surgery. History of epileptic seizures at the time of surgery (OR, 7.61; 95% CI, 1.67-85.42; P = .003) and partial resection of the CA and/or of the hemosiderin rim (OR, 12.02; 95% CI, 3.01-48.13; P < .001) are independent predictors of uncontrolled seizures postoperatively. Inability to work at the time of surgery (OR, 19.54; 95% CI, 1.90-425.48; P = .050), Karnofsky Performance Status ≤ 70 (OR, 51.20; 95% CI, 1.20-2175.37; P = .039), uncontrolled seizures postoperatively (OR, 105.33; 95% CI, 4.32-2566.27; P = .004), and worsening of cognitive functions postoperatively (OR, 13.71; 95% CI, 1.06-176.66; P = .045) are independent predictors of inability to work postoperatively.CONCLUSION: The functional-based resection using intraoperative functional brain mapping allows safe resection of CA and the peripheral hemosiderin rim located within or close to eloquent brain areas. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
653 | a Cavernous angioma | |
653 | a Epilepsy | |
653 | a Intraoperative brain mapping | |
653 | a Outcome | |
653 | a Return to work | |
653 | a Seizures | |
653 | a Surgery | |
700 | 1 | a Goodden, John R4 aut |
700 | 1 | a Colle, Henry4 aut |
700 | 1 | a Wager, Michel4 aut |
700 | 1 | a De Witt Hamer, Philip C4 aut |
700 | 1 | a Smits, Anjau Gothenburg University,Göteborgs universitet,Uppsala universitet,Neurologi,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xsmita |
700 | 1 | a Bello, Lorenzo4 aut |
700 | 1 | a Tate, Matthew4 aut |
700 | 1 | a Spena, Giannantonio4 aut |
700 | 1 | a Bresson, Damien4 aut |
700 | 1 | a Capelle, Laurent4 aut |
700 | 1 | a Robles, Santiago Gil4 aut |
700 | 1 | a Sarubbo, Silvio4 aut |
700 | 1 | a Rydenhag, Bertil,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xrydbe |
700 | 1 | a Martino, Juan4 aut |
700 | 1 | a Meyer, Bernhard4 aut |
700 | 1 | a Fontaine, Denys4 aut |
700 | 1 | a Reyns, Nicolas4 aut |
700 | 1 | a Schichor, Christian4 aut |
700 | 1 | a Metellus, Philippe4 aut |
700 | 1 | a Colle, David4 aut |
700 | 1 | a Robert, Erik4 aut |
700 | 1 | a Noens, Bonny4 aut |
700 | 1 | a Muller, Peter4 aut |
700 | 1 | a Rossi, Marco4 aut |
700 | 1 | a Nibali, Marco Conti4 aut |
700 | 1 | a Papagno, Costanza4 aut |
700 | 1 | a Galbarritu, Lara4 aut |
700 | 1 | a Ruiz de Gopegui, Edurne4 aut |
700 | 1 | a Chioffi, Franco4 aut |
700 | 1 | a Bucheli, Carlos4 aut |
700 | 1 | a Krieg, Sandro M4 aut |
700 | 1 | a Wostrack, Maria4 aut |
700 | 1 | a Yusupov, Natan4 aut |
700 | 1 | a Visser, Victoria4 aut |
700 | 1 | a Baaijen, Johannes C4 aut |
700 | 1 | a Roux, Alexandre4 aut |
700 | 1 | a Dezamis, Edouard4 aut |
700 | 1 | a Mandonnet, Emmanuel4 aut |
700 | 1 | a Corns, Robert4 aut |
700 | 1 | a Duffau, Hugues4 aut |
700 | 1 | a Pallud, Johan4 aut |
710 | 2 | a Uppsala universitetb Neurologi4 org |
773 | 0 | t Neurosurgeryd : Ovid Technologies (Wolters Kluwer Health)g 85:4, s. E702-E713q 85:4<E702-E713x 0148-396Xx 1524-4040 |
856 | 4 | u https://academic.oup.com/neurosurgery/issue-pdf/89/6/41394931 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-380937 |
856 | 4 8 | u https://doi.org/10.1093/neuros/nyz063 |
856 | 4 8 | u https://gup.ub.gu.se/publication/278943 |
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