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FältnamnIndikatorerMetadata
00006163naa a2200961 4500
001oai:DiVA.org:uu-380937
003SwePub
008190402s2019 | |||||||||||000 ||eng|
009oai:gup.ub.gu.se/278943
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3809372 URI
024a https://doi.org/10.1093/neuros/nyz0632 DOI
024a https://gup.ub.gu.se/publication/2789432 URI
040 a (SwePub)uud (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Zanello, Marc4 aut
2451 0a Predictors of Epileptic Seizures and Ability to Work in Supratentorial Cavernous Angioma Located Within Eloquent Brain Areas
264 c 2019-10
264 1b Ovid Technologies (Wolters Kluwer Health),c 2019
338 a print2 rdacarrier
520 a BACKGROUND: The postoperative outcomes and the predictors of seizure control are poorly studied for supratentorial cavernous angiomas (CA) within or close to the eloquent brain area.OBJECTIVE: To assess the predictors of preoperative seizure control, postoperative seizure control, and postoperative ability to work, and the safety of the surgery.METHODS: Multicenter international retrospective cohort analysis of adult patients benefitting from a functional-based surgical resection with intraoperative functional brain mapping for a supratentorial CA within or close to eloquent brain areas.RESULTS: A total of 109 patients (66.1% women; mean age 38.4 ± 12.5 yr), were studied. Age >38 yr (odds ratio [OR], 7.33; 95% confidence interval [CI], 1.53-35.19; P = .013) and time to surgery > 12 mo (OR, 18.21; 95% CI, 1.11-296.55; P = .042) are independent predictors of uncontrolled seizures at the time of surgery. Focal deficit (OR, 10.25; 95% CI, 3.16-33.28; P < .001) is an independent predictor of inability to work at the time of surgery. History of epileptic seizures at the time of surgery (OR, 7.61; 95% CI, 1.67-85.42; P = .003) and partial resection of the CA and/or of the hemosiderin rim (OR, 12.02; 95% CI, 3.01-48.13; P < .001) are independent predictors of uncontrolled seizures postoperatively. Inability to work at the time of surgery (OR, 19.54; 95% CI, 1.90-425.48; P = .050), Karnofsky Performance Status ≤ 70 (OR, 51.20; 95% CI, 1.20-2175.37; P = .039), uncontrolled seizures postoperatively (OR, 105.33; 95% CI, 4.32-2566.27; P = .004), and worsening of cognitive functions postoperatively (OR, 13.71; 95% CI, 1.06-176.66; P = .045) are independent predictors of inability to work postoperatively.CONCLUSION: The functional-based resection using intraoperative functional brain mapping allows safe resection of CA and the peripheral hemosiderin rim located within or close to eloquent brain areas.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653 a Cavernous angioma
653 a Epilepsy
653 a Intraoperative brain mapping
653 a Outcome
653 a Return to work
653 a Seizures
653 a Surgery
700a Goodden, John R4 aut
700a Colle, Henry4 aut
700a Wager, Michel4 aut
700a De Witt Hamer, Philip C4 aut
700a Smits, Anjau Gothenburg University,Göteborgs universitet,Uppsala universitet,Neurologi,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xsmita
700a Bello, Lorenzo4 aut
700a Tate, Matthew4 aut
700a Spena, Giannantonio4 aut
700a Bresson, Damien4 aut
700a Capelle, Laurent4 aut
700a Robles, Santiago Gil4 aut
700a Sarubbo, Silvio4 aut
700a Rydenhag, Bertil,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xrydbe
700a Martino, Juan4 aut
700a Meyer, Bernhard4 aut
700a Fontaine, Denys4 aut
700a Reyns, Nicolas4 aut
700a Schichor, Christian4 aut
700a Metellus, Philippe4 aut
700a Colle, David4 aut
700a Robert, Erik4 aut
700a Noens, Bonny4 aut
700a Muller, Peter4 aut
700a Rossi, Marco4 aut
700a Nibali, Marco Conti4 aut
700a Papagno, Costanza4 aut
700a Galbarritu, Lara4 aut
700a Ruiz de Gopegui, Edurne4 aut
700a Chioffi, Franco4 aut
700a Bucheli, Carlos4 aut
700a Krieg, Sandro M4 aut
700a Wostrack, Maria4 aut
700a Yusupov, Natan4 aut
700a Visser, Victoria4 aut
700a Baaijen, Johannes C4 aut
700a Roux, Alexandre4 aut
700a Dezamis, Edouard4 aut
700a Mandonnet, Emmanuel4 aut
700a Corns, Robert4 aut
700a Duffau, Hugues4 aut
700a Pallud, Johan4 aut
710a Uppsala universitetb Neurologi4 org
773t Neurosurgeryd : Ovid Technologies (Wolters Kluwer Health)g 85:4, s. E702-E713q 85:4<E702-E713x 0148-396Xx 1524-4040
856u https://academic.oup.com/neurosurgery/issue-pdf/89/6/41394931
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-380937
8564 8u https://doi.org/10.1093/neuros/nyz063
8564 8u https://gup.ub.gu.se/publication/278943

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