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Search: WFRF:(Vazquez del Mercado M) > (2015-2019) > The EuroMyositis re...

  • Lilleker, JB (author)

The EuroMyositis registry: an international collaborative tool to facilitate myositis research

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2017-08-30
  • BMJ,2018

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:137244055
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137244055URI
  • https://doi.org/10.1136/annrheumdis-2017-211868DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data.MethodsCross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated.ResultsOf 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001).Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001).ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases (‘V’ sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%.ConclusionThis large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vencovsky, J (author)
  • Wang, GC (author)
  • Wedderburn, LR (author)
  • Diederichsen, LP (author)
  • Schmidt, J (author)
  • Oakley, P (author)
  • Benveniste, O (author)
  • Danieli, MG (author)
  • Danko, K (author)
  • Thuy, NTP (author)
  • Vazquez-Del Mercado, M (author)
  • Andersson, H (author)
  • De Paepe, B (author)
  • debleecker, JL (author)
  • Maurer, B (author)
  • McCann, LJ (author)
  • Pipitone, N (author)
  • McHugh, N (author)
  • Betteridge, ZE (author)
  • New, P (author)
  • Cooper, RG (author)
  • Ollier, WE (author)
  • Lamb, JA (author)
  • Krogh, NS (author)
  • Lundberg, IEKarolinska Institutet (author)
  • Chinoy, H (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Annals of the rheumatic diseases: BMJ77:1, s. 30-391468-20600003-4967

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