WFRF:(Vazquez del Mercado M)
Sökning: WFRF:(Vazquez del Mercado M) > (2015-2019) > The EuroMyositis re...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03884naa a2200577 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:137244055 | |
| 003 | SwePub | |
| 008 | 240701s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1372440552 URI |
| 024 | 7 | a https://doi.org/10.1136/annrheumdis-2017-2118682 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lilleker, JB4 aut |
| 245 | 1 0 | a The EuroMyositis registry: an international collaborative tool to facilitate myositis research |
| 264 | c 2017-08-30 | |
| 264 | 1 | b BMJ,c 2018 |
| 520 | a The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data.MethodsCross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated.ResultsOf 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001).Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001).ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases (‘V’ sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%.ConclusionThis large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients. | |
| 700 | 1 | a Vencovsky, J4 aut |
| 700 | 1 | a Wang, GC4 aut |
| 700 | 1 | a Wedderburn, LR4 aut |
| 700 | 1 | a Diederichsen, LP4 aut |
| 700 | 1 | a Schmidt, J4 aut |
| 700 | 1 | a Oakley, P4 aut |
| 700 | 1 | a Benveniste, O4 aut |
| 700 | 1 | a Danieli, MG4 aut |
| 700 | 1 | a Danko, K4 aut |
| 700 | 1 | a Thuy, NTP4 aut |
| 700 | 1 | a Vazquez-Del Mercado, M4 aut |
| 700 | 1 | a Andersson, H4 aut |
| 700 | 1 | a De Paepe, B4 aut |
| 700 | 1 | a debleecker, JL4 aut |
| 700 | 1 | a Maurer, B4 aut |
| 700 | 1 | a McCann, LJ4 aut |
| 700 | 1 | a Pipitone, N4 aut |
| 700 | 1 | a McHugh, N4 aut |
| 700 | 1 | a Betteridge, ZE4 aut |
| 700 | 1 | a New, P4 aut |
| 700 | 1 | a Cooper, RG4 aut |
| 700 | 1 | a Ollier, WE4 aut |
| 700 | 1 | a Lamb, JA4 aut |
| 700 | 1 | a Krogh, NS4 aut |
| 700 | 1 | a Lundberg, IEu Karolinska Institutet4 aut |
| 700 | 1 | a Chinoy, H4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Annals of the rheumatic diseasesd : BMJg 77:1, s. 30-39q 77:1<30-39x 1468-2060x 0003-4967 |
| 856 | 4 | u https://ard.bmj.com/content/annrheumdis/77/1/30.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:137244055 |
| 856 | 4 8 | u https://doi.org/10.1136/annrheumdis-2017-211868 |
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