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FältnamnIndikatorerMetadata
00005226naa a2200517 4500
001oai:DiVA.org:su-139929
003SwePub
008170220s2017 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-396691
009oai:prod.swepub.kib.ki.se:135789202
009oai:DiVA.org:liu-134640
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1399292 URI
0247 a https://doi.org/10.1080/0284186X.2017.12932892 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3966912 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1357892022 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1346402 URI
040 a (SwePub)sud (SwePub)uud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lindblom, Emelyu Stockholms universitet,Fysikum,Stockholm University, Sweden4 aut0 (Swepub:su)emli3946
2451 0a Defining the hypoxic target volume based on positron emission tomography for image guided radiotherapy – the influence of the choice of the reference region and conversion function
264 1a Oxfordshire :b Taylor & Francis,c 2017
338 a print2 rdacarrier
500 a Funding agencies: European Union; Cancer Research Foundations of Radiumhemmet
520 a Background: Hypoxia imaged by positron emission tomography (PET) is a potential target for optimization in radiotherapy. However, the implementation of this approach with respect to the conversion of intensities in the images into oxygenation and radiosensitivity maps is not straightforward. This study investigated the feasibility of applying two conversion approaches previously derived for 18F-labeled fluoromisonidazole (18F-FMISO)-PET images for the hypoxia tracer 18F-flortanidazole (18F-HX4).Material and methods: Ten non-small-cell lung cancer patients imaged with 18F-HX4 before the start of radiotherapy were considered in this study. PET image uptake was normalized to a well-oxygenated reference region and subsequently linear and non-linear conversions were used to determine tissue oxygenations maps. These were subsequently used to delineate hypoxic volumes based partial oxygen pressure (pO2) thresholds. The results were compared to hypoxic volumes segmented using a tissue-to-background ratio of 1.4 for 18F-HX4 uptake.Results: While the linear conversion function was not found to result in realistic oxygenation maps, the non-linear function resulted in reasonably sized sub-volumes in good agreement with uptake-based segmented volumes for a limited range of pO2 thresholds. However, the pO2 values corresponding to this range were significantly higher than what is normally considered as hypoxia. The similarity in size, shape, and relative location between uptake-based sub-volumes and volumes based on the conversion to pO2 suggests that the relationship between uptake and pO2 is similar for 18F-FMISO and 18F-HX4, but that the model parameters need to be adjusted for the latter.Conclusions: A non-linear conversion function between uptake and oxygen partial pressure for 18F-FMISO-PET could be applied to 18F-HX4 images to delineate hypoxic sub-volumes of similar size, shape, and relative location as based directly on the uptake. In order to apply the model for e.g., dose-painting, new parameters need to be derived for the accurate calculation of dose-modifying factors for this tracer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a medicinsk strålningsfysik
653 a Medical Radiation Physics
7001 a Dasu, Alexandruu Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,The Skandion Clinic, Uppsala, Sweden4 aut0 (Swepub:liu)aleda92
7001 a Uhrdin, Johanu RaySearch Laboratories AB, Sweden4 aut
7001 a Even, Aniek J. G.u Maastricht University Medical Center, Maastricht, The Netherlands4 aut
7001 a van Elmpt, Wouteru Maastricht University Medical Center, Maastricht, The Netherlands4 aut
7001 a Lambin, Philippeu Maastricht University Medical Center, Maastricht, The Netherlands4 aut
7001 a Wersäll, Peteru Karolinska Institutet,Karolinska University Hospital, Stockholm, Sweden4 aut
7001 a Toma-Dasu, Iulianau Karolinska Institutet,Stockholms universitet,Fysikum,Stockholm University and Karolinska Institutet, Sweden4 aut0 (Swepub:su)iuda0736
7102 a Stockholms universitetb Fysikum4 org
7730 t Acta Oncologicad Oxfordshire : Taylor & Francisg 56:6, s. 819-825q 56:6<819-825x 0284-186Xx 1651-226X
8564 u https://doi.org/10.1080/0284186X.2017.1293289y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-139929
8564 8u https://doi.org/10.1080/0284186X.2017.1293289
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396691
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:135789202
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-134640

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