Detection of slow-cycling and stem/progenitor cells in different regions of rat Achilles tendon: response to treadmill exercise

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Fältnamn	Indikatorer	Metadata
000		04577naa a2200385 4500
001		oai:gup.ub.gu.se/175121
003		SwePub
008		240528s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:126944650
024	7	a https://gup.ub.gu.se/publication/1751212 URI
024	7	a https://doi.org/10.1007/s00167-013-2446-72 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1269446502 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Runesson, Eva,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics4 aut0 (Swepub:gu)xrunev
245	1 0	a Detection of slow-cycling and stem/progenitor cells in different regions of rat Achilles tendon: response to treadmill exercise
264		c 2013-02-12
264	1	b Springer Science and Business Media LLC,c 2013
520		a PURPOSE: Tendons generally exhibit poor healing capacity, probably due to slow cell regeneration potential and low vascularization. The potential to regenerate may partly be due to activation of stem/progenitor cells localized in the tendon or its vicinity. In the present study, we attempted to determine where in the rat Achilles tendon stem/progenitor cells reside and to investigate the effect of exercise on cell proliferation in the in vivo situation. METHOD: We used bromodeoxyuridine (BrdU) labelling to investigate proliferation and label-retaining cells (i.e. slow-cycling cells) in non-exercised and exercised rats, in combination with immunostaining of the stem cell marker nucleostemin. Rat Achilles tendons were harvested 14, 28, 56 and 105days after BrdU administration. RESULTS: We found the proportion of stem/progenitor cells to be twice as high in the distal tendon (DT) compared with the mid/proximal tendon (MPT) and that paratenon/endotenon regions appear to host a pool of existing stem/progenitor cells. Exercise increased the BrdU-stained cell population after 14days only (DT region p=0.032, MPT p=0.065), indicating effect mainly on more differentiated cells, since the nucleostemin-positive cells (i.e. stem/progenitor cells) remained unaffected in the intact Achilles tendon. CONCLUSION: Stem/progenitor cells exist in several areas of the rat Achilles tendon which implies a possible stem cell regeneration pool of different origins. The distal region has twice the amount of stem/progenitor cells compared with the mid/proximal region, indicating a potentially higher stem cell activity in this tissue. Daily moderate exercise (treadmill running) mainly improves in vivo cell proliferation in rapidly proliferating cells, whereas the stem/progenitor pool remains constant.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
653		a Achilles tendon Stem/progenitor cells Physical exercise BrdU labelling Nucleostemin Cell proliferation
700	1	a Ackermann, Paulu Karolinska Institutet4 aut
700	1	a Brisby, Helena,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics4 aut0 (Swepub:gu)xbrish
700	1	a Karlsson, Jón,d 1953u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics4 aut0 (Swepub:gu)xkajon
700	1	a Eriksson, Bengt I.,d 1946u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics4 aut0 (Swepub:gu)xerben
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för ortopedi4 org
773	0	t Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKAd : Springer Science and Business Media LLCg 21:7, s. 1694-1703q 21:7<1694-1703x 1433-7347
773	0	t Knee Surgery, Sports Traumatology, Arthroscopyd : Springer Science and Business Media LLCg 21:7, s. 1694-1703q 21:7<1694-1703x 0942-2056
856	4 8	u https://gup.ub.gu.se/publication/175121
856	4 8	u https://doi.org/10.1007/s00167-013-2446-7
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:126944650

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Av författaren/redakt...: Runesson, Eva, 1 ...; Ackermann, Paul; Brisby, Helena, ...; Karlsson, Jón, 1 ...; Eriksson, Bengt ...

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