Composition, architecture, and functional implications of the connective tissue network of the extraocular muscles

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McLoon, Linda K. (författare)

Composition, architecture, and functional implications of the connective tissue network of the extraocular muscles

Artikel/kapitelEngelska2018

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Rockville :The Association for Research in Vision and Ophthalmology,2018
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LIBRIS-ID:oai:DiVA.org:umu-146324
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146324URI
https://doi.org/10.1167/iovs.17-23003DOI

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Språk:engelska
Sammanfattning på:engelska

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Purpose: We examined the pattern and extent of connective tissue distribution in the extraocular muscles (EOMs) and determined the ability of the interconnected connective tissues to disseminate force laterally.Methods: Human EOMs were examined for collagens I, III, IV, and VI; fibronectin; laminin; and elastin using immunohistochemistry. Connective tissue distribution was examined with scanning electron microscopy. Rabbit EOMs were examined for levels of force transmission longitudinally and transversely using in vitro force assessment.Results: Collagens I, III, and VI localized to the endomysium, perimysium, and epimysium. Collagen IV, fibronectin, and laminin localized to the basal lamina surrounding all myofibers. All collagens localized similarly in the orbital and global layers throughout the muscle length. Elastin had the most irregular pattern and ran longitudinally and circumferentially throughout the length of all EOMs. Scanning electron microscopy showed these elements to be extensively interconnected, from endomysium through the perimysium to the epimysium surrounding the whole muscle. In vitro physiology demonstrated force generation in the lateral dimension, presumably through myofascial transmission, which was always proportional to the force generated in the longitudinally oriented muscles.Conclusions: A striking connective tissue matrix interconnects all the myofibers and extends, via perimysial connections, to the epimysium. These interconnections are significant and allow measurable force transmission laterally as well as longitudinally, suggesting that they may contribute to the nonlinear force summation seen in motor unit recording studies. This provides strong evidence that separate compartmental movements are unlikely as no region is independent of the rest of the muscle.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oftalmologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Ophthalmology hsv//eng
extraocular muscles
connective tissue
collagen
muscle force
scanning electron microscopy
perimysium
epimysium

Biuppslag (personer, institutioner, konferenser, titlar ...)

Vicente, AndréUmeå universitet,Oftalmiatrik(Swepub:umu)anvi0153 (författare)
Fitzpatrick, Krysta R. (författare)
Lindström, MonaUmeå universitet,Anatomi(Swepub:umu)moli0003 (författare)
Pedrosa Domellöf, FatimaUmeå universitet,Oftalmiatrik,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)fape0001 (författare)
Umeå universitetOftalmiatrik (creator_code:org_t)

Sammanhörande titlar

Ingår i:Investigative Ophthalmology and Visual ScienceRockville : The Association for Research in Vision and Ophthalmology59:1, s. 322-3290146-04041552-5783

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Av författaren/redakt...: McLoon, Linda K.; Vicente, André; Fitzpatrick, Kry ...; Lindström, Mona; Pedrosa Domellöf ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Oftalmologi

Artiklar i publikationen: Investigative Op ...

Av lärosätet: Umeå universitet

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