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WFRF:(Andersson Marie A.)
 

Sökning: WFRF:(Andersson Marie A.) > Peripheral inflamma...

  • Lampa, JonKarolinska Institutet (författare)

Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice.

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • 2012-07-16
  • Proceedings of the National Academy of Sciences,2012
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-441461
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441461URI
  • https://doi.org/10.1073/pnas.1118748109DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:125105845URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • During peripheral immune activation caused by an infection or an inflammatory condition, the innate immune response signals to the brain and causes an up-regulation of central nervous system (CNS) cytokine production. Central actions of proinflammatory cytokines, in particular IL-1β, are pivotal for the induction of fever and fatigue. In the present study, the influence of peripheral chronic joint inflammatory disease in rheumatoid arthritis (RA) on CNS inflammation was investigated. Intrathecal interleukin (IL)-1β concentrations were markedly elevated in RA patients compared with controls or with patients with multiple sclerosis. Conversely, the anti-inflammatory IL-1 receptor antagonist and IL-4 were decreased in RA cerebrospinal fluid (CSF). Tumor necrosis factor and IL-6 levels in the CSF did not differ between patients and controls. Concerning IL-1β, CSF concentrations in RA patients were higher than in serum, indicating local production in the CNS, and there was a positive correlation between CSF IL-1β and fatigue assessments. Next, spinal inflammation in experimental arthritis was investigated. A marked increase of IL-1β, IL-18, and tumor necrosis factor, but not IL-6 mRNA production, in the spinal cord was observed, coinciding with increased arthritis scores in the KBxN serum transfer model. These data provide evidence that peripheral inflammation such as arthritis is associated with an immunological activation in the CNS in both humans and mice, suggesting a possible therapeutic target for centrally affecting conditions as fatigue in chronic inflammatory diseases, for which to date there are no specific treatments.

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Westman, Marie (författare)
  • Kadetoff, Diana (författare)
  • Agréus, Anna Nordenstedt (författare)
  • Le Maître, ErwanKarolinska Institutet (författare)
  • Gillis-Haegerstrand, CarolineKarolinska Institutet (författare)
  • Andersson, MagnusKarolinska Institutet (författare)
  • Khademi, MohsenKarolinska Institutet (författare)
  • Corr, Maripat (författare)
  • Christianson, Christina A (författare)
  • Delaney, AdaKarolinska Institutet (författare)
  • Yaksh, Tony L (författare)
  • Kosek, EvaKarolinska Institutet(Swepub:uu)evako353 (författare)
  • Svensson, Camilla IKarolinska Institutet (författare)
  • Karolinska Institutet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences109:31, s. 12728-330027-84241091-6490

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