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Multimodal ex vivo methods reveal that Gd-rich corrosion byproducts remain at the implant site of biodegradable Mg-Gd screws

Peruzzi, Niccolò (author)
Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
Galli, Silvia (author)
Malmö University,Malmö universitet,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces
Helmholz, Heike (author)
Helmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht
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Kardjilov, Nikolay (author)
Helmholtz Centre for Materials and Energy, Germany,Helmholtz-Zentrum Berlin für Materialien und Energie GmbH
Krüger, Diana (author)
Helmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht
Markötter, Henning (author)
Bundesanstalt für Materialforschung und-prüfung, Germany,Federal Institute for Material Research and Testing (BAM) Germany
Moosmann, Julian (author)
Helmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht
Orlov, Dmytro (author)
Lund University,Lunds universitet,Materialteknik,Institutionen för maskinvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Materials Engineering,Department of Mechanical Engineering Sciences,Departments at LTH,Faculty of Engineering, LTH
Prgomet, Zdenka (author)
Malmö University,Malmö universitet,Odontologiska fakulteten (OD)
Willumeit-Römer, Regine (author)
Helmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht
Wennerberg, Ann, 1955 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för odontologi, sektion 2,Institute of Odontology, Section 2
Bech, Martin (author)
Lund University,Lunds universitet,X-ray Phase Contrast,Forskargrupper vid Lunds universitet,Lund University Research Groups
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 (creator_code:org_t)
Elsevier, 2021
2021
English.
In: Acta Biomaterialia. - : Elsevier. - 1742-7061 .- 1878-7568. ; 136, s. 582-591
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Extensive research is being conducted on magnesium (Mg) alloys for bone implant manufacturing, due to their biocompatibility, biodegradability and mechanical properties. Gadolinium (Gd) is among the most promising alloying elements for property control in Mg alloy implants; however, its toxicity is controversial. Investigating Gd behavior during implant corrosion is thus of utmost importance. In this study, we analyzed the degradation byproducts at the implant site of biodegradable Mg-5Gd and Mg-10Gd implants after 12 weeks healing time, using a combination of different imaging techniques: histology, energy-dispersive x-ray spectroscopy (EDX), x-ray microcomputed tomography (µCT) and neutron µCT. The main finding has been that, at the healing time in exam, the corrosion appears to have involved only the Mg component, which has been substituted by calcium and phosphorus, while the Gd remains localized at the implant site. This was observed in 2D by means of EDX maps and extended to 3D with a novel application of neutron tomography. X-ray fluorescence analysis of the main excretory organs also did not reveal any measurable accumulation of Gd, further reinforcing the conclusion that very limited or no removal at all of Gd-alloy happened during degradation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopaedics (hsv//eng)
NATURVETENSKAP  -- Fysik -- Annan fysik (hsv//swe)
NATURAL SCIENCES  -- Physical Sciences -- Other Physics Topics (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Materialteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Materials Engineering (hsv//eng)

Keyword

Molecular Biology
Biomedical Engineering
Biochemistry
Biomaterials
General Medicine
Biotechnology
Hälsa och samhälle
Health and society
Biodegradable implant
Energy-dispersive x-ray spectroscopy
Magnesium-gadolinium alloy
Micro-computed tomography
Multimodal analysis
Absorbable Implants
Alloys
Bone Screws
Corrosion
Gadolinium
Magnesium
pharmacology
Materials Testing
X-Ray Microtomography

Publication and Content Type

ref (subject category)
art (subject category)

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