Complement inhibition in biomaterial- and biosurface-induced thromboinflammation

Sökning: L773:1044 5323 > Complement inhibiti...

Ekdahl, Kristina N.Linnéuniversitetet,Uppsala universitet,Klinisk immunologi,Linnaeus Univ, Linnaeus Ctr Biomat Chem, SE-39182 Kalmar, Sweden.,Institutionen för kemi och biomedicin (KOB),Uppsala University,Linnaeus Ctr Biomat Chem, BMC (författare)

Therapeutic medicine today includes a vast number of procedures involving the use of biomaterials, transplantation of therapeutic cells or cell clusters, as well as of solid organs. These treatment modalities are obviously of great benefit to the patient, but also present a great challenge to the innate immune system, since they involve direct exposure of non-biological materials, cells of non-hematological origin as well as endothelial cells, damaged by ischemia-perfusion in solid organs to proteins and cells in the blood. The result of such an exposure may be an inappropriate activation of the complement and contact/kallikrein systems, which produce mediators capable of triggering the platelets and PMNs and monocytes, which can ultimately result in thrombotic and inflammatory (i.e., a thrombo-inflammatory) response to the treatment modality. In this concept review, we give an overview of the mechanisms of recognition within the innate immunity system, with the aim to identify suitable points for intervention. Finally, we discuss emerging and promising techniques for surface modification of biomaterials and cells with specific inhibitors in order to diminish thromboinflammation and improve clinical outcome.

Huang, ShanLinnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC(Swepub:lnu)shhuac (författare)
Nilsson, BoUppsala universitet,Klinisk immunologi,Uppsala University(Swepub:uu)bonils (författare)
Teramura, YujiUppsala universitet,Klinisk immunologi,Univ Tokyo, Dept Bioengn, Bunkyo Ku, 7-3-1Hongo, Tokyo 1138656, Japan,Uppsala University;The University of Tokyo, Japan(Swepub:uu)yujte186 (författare)
Uppsala universitetKlinisk immunologi (creator_code:org_t)

Av författaren/redakt...: Ekdahl, Kristina ...; Huang, Shan; Nilsson, Bo; Teramura, Yuji

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Immunologi inom ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Mikrobiologi ino ...

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