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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002446naa a2200289 4500
001oai:DiVA.org:uu-318284
003SwePub
008220116s1985 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3182842 URI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Schoenberg, M H4 aut
2451 0a Hemorrhagic shock in the dog. I. Correlation between survival and severity of shock.
264 1c 1985
338 a print2 rdacarrier
520 a A prerequisite elucidating the pathomechanism of hemorrhagic shock are reproducible experimental models, leading to a predictable outcome. Two concepts have been reported to be a good predictor for the outcome both employing a fixed hypotension level: total oxygen deficit and shed blood volume uptake. To correlate these two models we subjected 31 dogs to a standardized hemorrhagic shock procedure. Besides determination of acid-base status, hematocrit, mean arterial pressure, and cardiac output, these two parameters were measured continuously. Seventeen dogs survived the shock procedure, 14 died within 24 h. During shock, neither oxygen deficit nor any other parameter mentioned above correlated with the final outcome of the shock state. The only significant difference between surviving and non-surviving animals during this period was the amount of uptake. The non-surviving dogs exhibited a higher uptake volume, indicating an incipient collapse of the microcirculation. Terminating the duration of hypotension at an uptake volume of 5% of the maximum shed blood, all animals survived, while after an uptake volume of 15% about 50% of the dogs died. Using uptake volumes of various degrees in a hemorrhagic shock model as the endpoint of the hypotensive stress, it seems possible to produce reliable survival rates.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
700a Smedegård, G4 aut
700a Gerdin, Bengt,d 1947-4 aut
700a Messmer, K4 aut
700a Arfors, K E4 aut
773t Research in experimental medicineg 185:1, s. 21-33q 185:1<21-33x 0300-9130x 1433-8580
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318284

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Schoenberg, M H
Smedegård, G
Gerdin, Bengt, 1 ...
Messmer, K
Arfors, K E
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Physiology
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Uppsala University

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