Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

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Fältnamn	Indikatorer	Metadata
000		07278naa a2201477 4500
001		oai:openarchive.ki.se:10616/47545
003		SwePub
008		240410s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:143157867
022		a 1756-994X
024	7	a 10616/475452 hdl
024	7	a http://hdl.handle.net/10616/475452 URI
024	7	a https://doi.org/10.1186/s13073-020-0716-92 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1431578672 URI
040		a (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Merid, Simon Kebedeu Karolinska Institutet4 aut
245	1 0	a Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
264		c 2020-03-02
264	1	a Stockholm :b Karolinska Institutet, Dept of Clinical Science and Education, Södersjukhuset,c 2020
338		a electronic2 rdacarrier
520		a Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods: We performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results: We identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P < 1.06 × 10- 7, of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions: We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.
700	1	a Novoloaca, Alexei4 aut
700	1	a Sharp, Gemma C4 aut
700	1	a Küpers, Leanne K4 aut
700	1	a Kho, Alvin T4 aut
700	1	a Roy, Ritu4 aut
700	1	a Gao, Lu4 aut
700	1	a Annesi-Maesano, Isabella4 aut
700	1	a Jain, Pooja4 aut
700	1	a Plusquin, Michelle4 aut
700	1	a Kogevinas, Manolis4 aut
700	1	a Allard, Catherine4 aut
700	1	a Vehmeijer, Florianne O4 aut
700	1	a Kazmi, Nabila4 aut
700	1	a Salas, Lucas A4 aut
700	1	a Rezwan, Faisal I4 aut
700	1	a Zhang, Hongmei4 aut
700	1	a Sebert, Sylvain4 aut
700	1	a Czamara, Darina4 aut
700	1	a Rifas-Shiman, Sheryl L4 aut
700	1	a Melton, Phillip Eu Karolinska Institutet4 aut
700	1	a Lawlor, Debbie A4 aut
700	1	a Pershagen, Göranu Karolinska Institutet4 aut
700	1	a Breton, Carrie V4 aut
700	1	a Huen, Karen4 aut
700	1	a Baiz, Nour4 aut
700	1	a Gagliardi, Luigi4 aut
700	1	a Nawrot, Tim S4 aut
700	1	a Corpeleijn, Eva4 aut
700	1	a Perron, Patriceu Karolinska Institutet4 aut
700	1	a Duijts, Liesbeth4 aut
700	1	a Nohr, Ellen Aagaard4 aut
700	1	a Bustamante, Mariona4 aut
700	1	a Ewart, Susan L4 aut
700	1	a Karmaus, Wilfried4 aut
700	1	a Zhao, Shanshan4 aut
700	1	a Page, Christian M4 aut
700	1	a Herceg, Zdenko4 aut
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Lahti, Jari4 aut
700	1	a Baccarelli, Andrea A4 aut
700	1	a Anderson, Denise4 aut
700	1	a Kachroo, Priyadarshini4 aut
700	1	a Relton, Caroline L4 aut
700	1	a Bergström, Annau Karolinska Institutet4 aut
700	1	a Eskenazi, Brenda4 aut
700	1	a Soomro, Munawar Hussain4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Snieder, Harold4 aut
700	1	a Bouchard, Luigi4 aut
700	1	a Jaddoe, Vincent W4 aut
700	1	a Sørensen, Thorkild I A4 aut
700	1	a Vrijheid, Martine4 aut
700	1	a Arshad, S Hasan4 aut
700	1	a Holloway, John W4 aut
700	1	a Håberg, Siri E4 aut
700	1	a Magnus, Per4 aut
700	1	a Dwyer, Terence4 aut
700	1	a Binder, Elisabeth B4 aut
700	1	a DeMeo, Dawn L4 aut
700	1	a Vonk, Judith M4 aut
700	1	a Newnham, John4 aut
700	1	a Tantisira, Kelan G4 aut
700	1	a Kull, Ingeru Karolinska Institutet4 aut
700	1	a Wiemels, Joseph L4 aut
700	1	a Heude, Barbara4 aut
700	1	a Sunyer, Jordi4 aut
700	1	a Nystad, Wenche4 aut
700	1	a Munthe-Kaas, Monica C4 aut
700	1	a Räikkönen, Katri4 aut
700	1	a Oken, Emily4 aut
700	1	a Huang, Rae-Chi4 aut
700	1	a Weiss, Scott T4 aut
700	1	a Antó, Josep Maria4 aut
700	1	a Bousquet, Jean4 aut
700	1	a Kumar, Ashish4 aut
700	1	a Söderhäll, Cillau Karolinska Institutet4 aut
700	1	a Almqvist, Catarinau Karolinska Institutet4 aut
700	1	a Cardenas, Andres4 aut
700	1	a Gruzieva, Olenau Karolinska Institutet4 aut
700	1	a Xu, Cheng-Jian4 aut
700	1	a Reese, Sarah E4 aut
700	1	a Kere, Juhau Karolinska Institutet4 aut
700	1	a Brodin, Petter4 aut
700	1	a Solomon, Olivia4 aut
700	1	a Wielscher, Matthias4 aut
700	1	a Holland, Nina4 aut
700	1	a Ghantous, Akram4 aut
700	1	a Hivert, Marie-France4 aut
700	1	a Felix, Janine F4 aut
700	1	a Koppelman, Gerard H4 aut
700	1	a London, Stephanie J4 aut
700	1	a Melén, Erik4 aut
710	2	a Karolinska Institutet
710	2	a Karolinska Institutet
710	2	a Karolinska Institutet4 org
773	0	t Genome Medicined Stockholm : Karolinska Institutet, Dept of Clinical Science and Education, Södersjukhusetx 1756-994X
856	4	u http://hdl.handle.net/10616/47545x primaryx Object in contextx freey FULLTEXT
856	4	u https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-020-0716-9
856	4 8	u http://hdl.handle.net/10616/47545
856	4 8	u https://doi.org/10.1186/s13073-020-0716-9
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:143157867

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Av författaren/redakt...: Merid, Simon Keb ...; Novoloaca, Alexe ...; Sharp, Gemma C; Küpers, Leanne K; Kho, Alvin T; Roy, Ritu; visa fler...; Gao, Lu; Annesi-Maesano, ...; Jain, Pooja; Plusquin, Michel ...; Kogevinas, Manol ...; Allard, Catherin ...; Vehmeijer, Flori ...; Kazmi, Nabila; Salas, Lucas A; Rezwan, Faisal I; Zhang, Hongmei; Sebert, Sylvain; Czamara, Darina; Rifas-Shiman, Sh ...; Melton, Phillip ...; Lawlor, Debbie A; Pershagen, Göran; Breton, Carrie V; Huen, Karen; Baiz, Nour; Gagliardi, Luigi; Nawrot, Tim S; Corpeleijn, Eva; Perron, Patrice; Duijts, Liesbeth; Nohr, Ellen Aaga ...; Bustamante, Mari ...; Ewart, Susan L; Karmaus, Wilfrie ...; Zhao, Shanshan; Page, Christian ...; Herceg, Zdenko; Jarvelin, Marjo- ...; Lahti, Jari; Baccarelli, Andr ...; Anderson, Denise; Kachroo, Priyada ...; Relton, Caroline ...; Bergström, Anna; Eskenazi, Brenda; Soomro, Munawar ...; Vineis, Paolo; Snieder, Harold; Bouchard, Luigi; Jaddoe, Vincent ...; Sørensen, Thorki ...; Vrijheid, Martin ...; Arshad, S Hasan; Holloway, John W; Håberg, Siri E; Magnus, Per; Dwyer, Terence; Binder, Elisabet ...; DeMeo, Dawn L; Vonk, Judith M; Newnham, John; Tantisira, Kelan ...; Kull, Inger; Wiemels, Joseph ...; Heude, Barbara; Sunyer, Jordi; Nystad, Wenche; Munthe-Kaas, Mon ...; Räikkönen, Katri; Oken, Emily; Huang, Rae-Chi; Weiss, Scott T; Antó, Josep Mari ...; Bousquet, Jean; Kumar, Ashish; Söderhäll, Cilla; Almqvist, Catari ...; Cardenas, Andres; Gruzieva, Olena; Xu, Cheng-Jian; Reese, Sarah E; Kere, Juha; Brodin, Petter; Solomon, Olivia; Wielscher, Matth ...; Holland, Nina; Ghantous, Akram; Hivert, Marie-Fr ...; Felix, Janine F; Koppelman, Gerar ...; London, Stephani ...; Melén, Erik; visa färre...

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