WFRF:(Burman P)
Sökning: WFRF:(Burman P) > (2010-2014) > Favorable long-term...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03990naa a2200433 4500 | |
| 001 | oai:lup.lub.lu.se:cc38fb1b-4316-4662-9e3e-b14f1f22465b | |
| 003 | SwePub | |
| 008 | 160401s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/19859862 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ghir.2011.01.0012 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Jorgensen, A. P.4 aut |
| 245 | 1 0 | a Favorable long-term effects of growth hormone replacement therapy on quality of life, bone metabolism, body composition and lipid levels in patients with adult-onset growth hormone deficiency |
| 264 | 1 | b Elsevier BV,c 2011 |
| 520 | a Objective: The goal of growth hormone (GH) replacement is to improve quality of life (QoL) and prevent the long-term complications of GH deficiency (GHD). Thirty-nine patients with adult-onset GH deficiency (AOGHD) who had originally participated in a randomized placebo-controlled crossover study involving treatment with either GH or placebo for nine months were enrolled in an open, 33-month follow-up study of the effects on QoL as well as bone and metabolic parameters. Methods: GH replacement was dosed individually to obtain IGF-I concentrations that were within the upper part of the normal range for age (mean + 1SD). The variables were assessed on five occasions during the study. Results: QoL, as assessed by the sum scores of HSCL-58, AGHDA, physical activity (KIMS question 11) and the dimension vitality in SF-36, improved. Markers of bone formation and resorption remained increased throughout the study period. Bone mineral area (BMA), bone mineral content (BMC) and bone mineral density (BMD) increased in both the lumbar (L2-L4) spine and total body. BMC and BMD increased in the femur. Hypogonadal women however, showed reduced bone mass during the study period. The changes in body fat mass (BFM) and lean body mass (LBM) were sustained throughout the long-term treatment (BFM -2.18 (+/-4.87) kg LBM by 2.01( +/-3.25) kg). Low-density lipoprotein cholesterol (LDL-C) levels were reduced by 0.6 (+/-1.1) mmol/l, and high-density lipoprotein cholesterol (HDL-C) levels increased by 0.2 (+/-0.3) mmol/l. No changes were observed in body weight, fasting total cholesterol, triglycerides, HbA1c and plasma glucose. Mean fasting insulin levels increased significantly from 110 pmol/l to 159 pmol/l, p <0.02. Conclusion: Long-term replacement of growth hormone in patients with AOGHD induces favorable effects on QoL as well as bone and metabolic parameters. An increase in insulin levels is also noteworthy. (C) 2011 Growth Hormone Research Society. Published by Elsevier Ltd. All rights reserved. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a Growth hormone | |
| 653 | a GH deficiency | |
| 653 | a Quality of life | |
| 653 | a Bone mineral density | |
| 653 | a Body composition | |
| 653 | a Insulin | |
| 653 | a Lipids | |
| 700 | 1 | a Fougner, K. J.4 aut |
| 700 | 1 | a Ueland, T.4 aut |
| 700 | 1 | a Gudmundsen, O.4 aut |
| 700 | 1 | a Burman, Piau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-bap |
| 700 | 1 | a Schreiner, T.4 aut |
| 700 | 1 | a Bollerslev, J.4 aut |
| 710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Growth Hormone & Igf Researchd : Elsevier BVg 21:2, s. 69-75q 21:2<69-75x 1532-2238x 1096-6374 |
| 856 | 4 | u http://dx.doi.org/10.1016/j.ghir.2011.01.001y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1985986 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ghir.2011.01.001 |
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