Allergy in severe asthma

It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and respiratory viral infections, and interaction between viruses and allergy further increases the risk of asthma exacerbations. Furthermore, fungal allergy has been shown to play an important role in severe asthma. Other contributing factors include smoking, pollution and work-related exposures. The 'Allergy and Asthma Severity' EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.

Bakirtas, A.Gazi University (author)
Bel, E.Academic Medical Center of University of Amsterdam (AMC) (author)
Custovic, A.Imperial College London (author)
Diamant, Z.Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Groningen(Swepub:lu)med-zdt (author)
Hamelmann, E.Evangelisches Krankenhaus Bielefeld (author)
Heffler, E.University of Catania (author)
Kalayci, O.Hacettepe University (author)
Saglani, S.Imperial College London (author)
Sergejeva, S.University of Tartu (author)
Seys, S.Catholic University of Leuven (author)
Simpson, A.University Hospital of South Manchester NHS Foundation Trust (author)
Bjermer, L.Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)lung-lbj (author)
University of CagliariGazi University (creator_code:org_t)

In:Allergy: European Journal of Allergy and Clinical Immunology: Wiley72:2, s. 207-2200105-4538

By the author/editor: Del Giacco, S. R ...; Bakirtas, A.; Bel, E.; Custovic, A.; Diamant, Z.; Hamelmann, E.; show more...; Heffler, E.; Kalayci, O.; Saglani, S.; Sergejeva, S.; Seys, S.; Simpson, A.; Bjermer, L.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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