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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004544naa a2200445 4500
001oai:DiVA.org:uu-535547
003SwePub
008240808s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:158860941
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5355472 URI
0247 a https://doi.org/10.1002/hem3.1212 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1588609412 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Abalo, Kossi D.u Uppsala universitet,Cancerprecisionsmedicin,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.4 aut0 (Swepub:uu)antko201
2451 0a Infections in patients with mantle cell lymphoma
264 1b John Wiley & Sons,c 2024
338 a electronic2 rdacarrier
520 a Advancements in treatments have significantly improved the prognosis for mantle cell lymphoma (MCL), and there is a growing population of survivors with an increased susceptibility to infections. We assessed the incidence of infections by clinical characteristics and treatment both before and after MCL diagnosis in Sweden. Patients with a diagnosis of MCL >= 18 years between 2007 and 2019 were included, along with up to 10 matched comparators. Infectious disease diagnosis and anti-infective drug dispensation were identified by the National Patient and the Prescribed Drug Registers, respectively. Patients and comparators were followed from the diagnosis/matching date until death, emigration, or June 30, 2020. Overall, 1559 patients and 15,571 comparators were followed for a median duration of 2.9 and 5 years, respectively. The infection rate among patients was twofold higher, RRadj = 2.14 (2.01-2.27), contrasted to the comparator group. There was a notable rise in infection rates already 4 years before MCL diagnosis, which reached a fourfold increase in the first year after diagnosis and persisted significantly increased for an additional 8 years. Among patients, 69% (n = 1080) experienced at least one infection during the first year of follow-up. Influenza, pneumonia, other bacterial infections, urinary tract infections, and acute upper respiratory infections were the most frequent. Notably, MCL remained to be the primary leading cause of death among patients (57%, n = 467/817). Infections as the main cause of death were rare (2.6%, n = 21). Our study highlights the importance of thoroughly assessing infectious morbidity when appraising new treatments. Further investigations are warranted to explore strategies for reducing infectious disease burden.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
7001 a Ekberg, Sarau Uppsala universitet,Cancerprecisionsmedicin,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.4 aut0 (Swepub:uu)sarek249
7001 a Andersson, Therese M. L.u Karolinska Institutet4 aut
7001 a Pahnke, Simonu Uppsala universitet,Cancerprecisionsmedicin4 aut0 (Swepub:uu)simpa740
7001 a Albertsson-Lindblad, Alexandrau Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Oncol, Lund, Sweden.4 aut
7001 a Smedby, Karin E.u Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden.4 aut
7001 a Jerkeman, Matsu Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Oncol, Lund, Sweden.4 aut
7001 a Glimelius, Ingrid,d 1975-u Uppsala universitet,Cancerprecisionsmedicin,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.4 aut0 (Swepub:uu)inggl846
7102 a Uppsala universitetb Cancerprecisionsmedicin4 org
7730 t HemaSphered : John Wiley & Sonsg 8:7q 8:7x 2572-9241
8564 u https://doi.org/10.1002/hem3.121y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1887477/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-535547
8564 8u https://doi.org/10.1002/hem3.121
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:158860941

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