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FältnamnIndikatorerMetadata
00007616naa a2200733 4500
001oai:gup.ub.gu.se/295295
003SwePub
008240528s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-173919
009oai:lup.lub.lu.se:d90c4873-8fd4-45ad-8588-1b2935544706
009oai:prod.swepub.kib.ki.se:144265286
0247 a https://gup.ub.gu.se/publication/2952952 URI
0247 a https://doi.org/10.1038/s41598-020-68130-y2 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1739192 URI
0247 a https://lup.lub.lu.se/record/d90c4873-8fd4-45ad-8588-1b29355447062 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442652862 URI
040 a (SwePub)gud (SwePub)umud (SwePub)lud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Jain, Ruchiu Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ruj
2451 0a Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes
264 c 2020-07-14
264 1b Springer Science and Business Media LLC,c 2020
520 a Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma metabolite markers associated with freedom from vascular complications in people with very long duration of type 1 diabetes (T1D). Individuals with T1D, who despite having longer than 30 years of diabetes duration never developed major macro- or microvascular complications (non-progressors; NP) were compared with those who developed vascular complications within 25 years from diabetes onset (rapid progressors; RP) in the Scandinavian PROLONG (n = 385) and DIALONG (n = 71) cohorts. The DIALONG study also included 75 healthy controls. Plasma metabolites were measured using gas and/or liquid chromatography coupled to mass spectrometry. Lower hepatic fatty liver indices were significant common feature characterized NPs in both studies. Higher insulin sensitivity and residual beta-cell function (C-peptide) were also associated with NPs in PROLONG. Protection from diabetic complications was associated with lower levels of the glycolytic metabolite pyruvate and APOCIII in PROLONG, and with lower levels of thiamine monophosphate and erythritol, a cofactor and intermediate product in the pentose phosphate pathway as well as higher phenylalanine, glycine and serine in DIALONG. Furthermore, T1D individuals showed elevated levels of picolinic acid as compared to the healthy individuals. The present findings suggest a potential beneficial shunting of glycolytic substrates towards the pentose phosphate and one carbon metabolism pathways to promote nucleotide biosynthesis in the liver. These processes might be linked to higher insulin sensitivity and lower liver fat content, and might represent a mechanism for protection from vascular complications in individuals with long-term T1D.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Ozgumus, T.u University of Bergen4 aut
7001 a Jensen, T. M.u University of Southern Denmark,Steno Diabetes Center Copenhagen4 aut
7001 a du Plessis, E.u University of Bergen4 aut
7001 a Keindl, M.u University of Bergen4 aut
7001 a Moller, C. L.u Steno Diabetes Center Copenhagen4 aut
7001 a Falhammar, H.u Karolinska Institutet4 aut
7001 a Nystrom, T.u Karolinska Institutet,Stockholm South General Hospital4 aut
7001 a Catrina, S. B.u Karolinska Institutet,Akademiskt specialistcentrum, Stockholm,Karolinska University Hospital4 aut
7001 a Jorneskog, G.u Karolinska Institutet,Danderyd Hospital4 aut
7001 a Jessen, L. E.u Technical University of Denmark4 aut
7001 a Forsblom, C.u Folkhälsan Research Center,University of Helsinki,Helsinki University Central Hospital4 aut
7001 a Haukka, J. K.u Helsinki University Central Hospital,Helsinki University of Technology,Folkhälsan Research Center4 aut
7001 a Groop, P. H.u Monash University,Folkhälsan Research Center,University of Helsinki,Helsinki University Central Hospital4 aut
7001 a Rossing, P.u University of Copenhagen,Steno Diabetes Center Copenhagen4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)4 aut0 (Swepub:lu)endo-lgr
7001 a Eliasson, Matsu Umeå University,Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)mael0021
7001 a Eliasson, Björn,d 1959u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xelibj
7001 a Brismar, K.u Karolinska Institutet,Karolinska University Hospital4 aut
7001 a Al-Majdoub, Mahmoudu Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups4 aut0 (Swepub:lu)med-ma22
7001 a Nilsson, Peter M.u Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
7001 a Taskinen, M. R.u University of Helsinki4 aut
7001 a Ferrannini, E.u CNR Institute of Clinical Physiology (IFC-CNR)4 aut
7001 a Spégel, Peteru Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)tekn-psp
7001 a Berg, T. J.u University of Oslo,Oslo university hospital4 aut
7001 a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Bergen4 aut0 (Swepub:lu)endo-vly
7102 a Diabetes - öpatofysiologib Forskargrupper vid Lunds universitet4 org
7730 t Scientific Reportsd : Springer Science and Business Media LLCg 10:1q 10:1x 2045-2322
8564 u https://www.nature.com/articles/s41598-020-68130-y.pdf
8564 u https://doi.org/10.1038/s41598-020-68130-yy Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1456686/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.1038/s41598-020-68130-yx freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/295295
8564 8u https://doi.org/10.1038/s41598-020-68130-y
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173919
8564 8u https://lup.lub.lu.se/record/d90c4873-8fd4-45ad-8588-1b2935544706
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144265286

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