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Sökning: WFRF:(Fekete Boglarka) > Patterns of care an...

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FältnamnIndikatorerMetadata
00006674naa a2200445 4500
001oai:gup.ub.gu.se/290277
003SwePub
008240528s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-414113
0247 a https://gup.ub.gu.se/publication/2902772 URI
0247 a https://doi.org/10.1371/journal.pone.02284802 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4141132 URI
040 a (SwePub)gud (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Werlenius, Katjau Gothenburg University,Göteborgs universitet,Extern,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,External,Institute of Clinical Sciences, Department of Oncology,Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.4 aut0 (Swepub:gu)xwerka
2451 0a Patterns of care and clinical outcome in assumed glioblastoma without tissue diagnosis: A population-based study of 131 consecutive patients.
264 c 2020-02-13
264 1b Public Library of Science (PLoS),c 2020
520 a Elderly patients with glioblastoma and an accumulation of negative prognostic factors have an extremely short survival. There is no consensus on the clinical management of these patients and many may escape histologically verified diagnosis. The primary aim of this study was to characterize this particular subgroup of patients with radiological glioblastoma diagnosis without histological verification. The secondary aim was to evaluate if oncological therapy was of benefit.Between November 2012 and June 2016, all consecutive patients presenting with a suspected glioblastoma in the western region of Sweden were registered in a population-based study. Of the 378 patients, 131 (35%) met the inclusion criteria of the present study by typical radiological features of glioblastoma without histological verification.The clinical characteristics of the 131 patients (72 men, 59 women) were: age ≥ 75 (n = 99, 76%), performance status according to Eastern Cooperative Oncology Group ≥ 2 (n = 93, 71%), significant comorbidity (n = 65, 50%) and multilobular tumors (n = 90, 69%). The overall median survival rate was 3.6 months. A subgroup of 44 patients (34%) received upfront treatment with temozolomide, with an overall radiological response rate of 34% and a median survival of 6.8 months, compared to 2.7 months for those receiving best supportive care only. Good performance status and temozolomide treatment were statistically significant favorable prognostic factors, while younger age was not.Thirty-five percent of patients with a radiological diagnosis of glioblastoma in our region lacked histological diagnosis. Apart from high age and poor performance status, they had more severe comorbidities and extensive tumor spread. Even for this poor prognostic group upfront treatment with temozolomide was shown of benefit in a subgroup of patients. Our data illustrate the need of non-invasive diagnostic methods to guide optimal individualized therapy for patients considered too fragile for neurosurgical biopsy.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Fekete, Boglarkau Gothenburg University,Göteborgs universitet,Extern,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,External,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.;Sahlgrens Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden.4 aut
7001 a Blomstrand, Malin,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Extern,Institute of Clinical Sciences, Department of Oncology,External,Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg, Sweden.4 aut0 (Swepub:gu)xjmalb
7001 a Carén, Helena,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Sahlgrenska Cancer Center,Department of Laboratory Medicine,Univ Gothenburg, Sahlgrenska Acad, Sahlgrenska Canc Ctr, Inst Biomed,Dept Lab Med, Gothenburg, Sweden.4 aut0 (Swepub:gu)xcareh
7001 a Jakola, Asgeir Storeu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Extern,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,External,Sahlgrens Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Neurosurg, Gothenburg, Sweden.4 aut0 (Swepub:gu)xjakas
7001 a Rydenhag, Bertil,d 1954u Gothenburg University,Göteborgs universitet,Extern,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,External,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Sahlgrens Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Neurosurg, Gothenburg, Sweden.4 aut0 (Swepub:gu)xrydbe
7001 a Smits, Anjau Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Extern,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,External,Landtblom: Neurovetenskap,Sahlgrens Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Neurol, Gothenburg, Sweden4 aut0 (Swepub:uu)anjasmit
7102 a Göteborgs universitetb Extern4 org
7730 t PloS oned : Public Library of Science (PLoS)g 15:2q 15:2x 1932-6203
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0228480&type=printable
8564 u https://doi.org/10.1371/journal.pone.0228480y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1445730/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/290277
8564 8u https://doi.org/10.1371/journal.pone.0228480
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414113

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