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  • Åkerman, Anna-KarinDepartment of Medicine, Örebro University Hospital, 701 85 Örebro, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden (författare)

Plasma-Metanephrines in Patients with Autoimmune Addison's Disease with and without Residual Adrenocortical Function

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • MDPI,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-106094
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-106094URI
  • https://doi.org/10.3390/jcm12103602DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-209380URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152732102URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Internal Medicine Association of NorwayRegional agreement on medical training and clinical research in Stockholm
  • PURPOSE: Residual adrenocortical function, RAF, has recently been demonstrated in one-third of patients with autoimmune Addison's disease (AAD). Here, we set out to explore any influence of RAF on the levels of plasma metanephrines and any changes following stimulation with cosyntropin.METHODS: We included 50 patients with verified RAF and 20 patients without RAF who served as controls upon cosyntropin stimulation testing. The patients had abstained from glucocorticoid and fludrocortisone replacement > 18 and 24 h, respectively, prior to morning blood sampling. The samples were obtained before and 30 and 60 min after cosyntropin stimulation and analyzed for serum cortisol, plasma metanephrine (MN), and normetanephrine (NMN) by liquid-chromatography tandem-mass pectrometry (LC-MS/MS).RESULTS: Among the 70 patients with AAD, MN was detectable in 33%, 25%, and 26% at baseline, 30 min, and 60 min after cosyntropin stimulation, respectively. Patients with RAF were more likely to have detectable MN at baseline (p = 0.035) and at the time of 60 min (p = 0.048) compared to patients without RAF. There was a positive correlation between detectable MN and the level of cortisol at all time points (p = 0.02, p = 0.04, p < 0.001). No difference was noted for NMN levels, which remained within the normal reference ranges.CONCLUSION: Even very small amounts of endogenous cortisol production affect MN levels in patients with AAD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sævik, Åse BjorvatnDepartment of Clinical Science, University of Bergen, 5021 Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway (författare)
  • Thorsby, Per MedbøeHormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, 0372 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, 0372 Oslo, Norway (författare)
  • Methlie, PaalDepartment of Clinical Science, University of Bergen, 5021 Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway; Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway (författare)
  • Quinkler, MarcusEndocrinology in Charlottenburg, 10627 Berlin, Germany (författare)
  • Jørgensen, Anders PalmstrømDepartment of Endocrinology, Oslo University Hospital, 0372 Oslo, Norway (författare)
  • Höybye, CharlotteDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden (författare)
  • Debowska, Aleksandra J.Department of Medicine, Vestfold Hospital Trust, 3103 Tønsberg, Norway (författare)
  • Nedrebø, Bjørn GunnarDepartment of Clinical Science, University of Bergen, 5021 Bergen, Norway; Department of Internal Medicine, Haugesund Hospital, 5528 Haugesund, Norway (författare)
  • Dahle, Anne LiseDepartment of Internal Medicine, Haugesund Hospital, 5528 Haugesund, Norway (författare)
  • Carlsen, SiriDepartment of Endocrinology, Stavanger University Hospital, 4068 Stavanger, Norway (författare)
  • Tomkowicz, AnetaDepartment of Medicine, Sørlandet Hospital, 4604 Kristiansand, Norway (författare)
  • Sollid, Stina ThereseDepartment of Medicine, Drammen Hospital, Vestre Viken Health Trust, 3004 Drammen, Norway (författare)
  • Nermoen, IngridDepartment of Endocrinology, Akershus University Hospital, 1478 Lørenskog, Norway (författare)
  • Grønning, KajaDepartment of Endocrinology, Akershus University Hospital, 1478 Lørenskog, Norway (författare)
  • Dahlqvist, PerUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)perdat96 (författare)
  • Grimnes, GuriDivision of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway; Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT the Arctic University of Norway, 9037 Tromsø, Norway (författare)
  • Skov, JakobDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden (författare)
  • Finnes, TrineSection of Endocrinology, Innlandet Hospital Trust, 2381 Hamar, Norway (författare)
  • Wahlberg, Jeanette,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Örebro University Hospital, 701 85 Örebro, Sweden,Department of Medicine, Örebro University Hospital, Örebro, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)jewg (författare)
  • Holte, Synnøve EmblemDepartment of Medicine, Sørlandet Hospital, 4838 Arendal, Norway (författare)
  • Simunkova, KaterinaDepartment of Clinical Science, University of Bergen, 5021 Bergen, Norway (författare)
  • Kämpe, OlleDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden (författare)
  • Husebye, Eystein SverreDepartment of Clinical Science, University of Bergen, 5021 Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway; Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden (författare)
  • Øksnes, MarianneDepartment of Clinical Science, University of Bergen, 5021 Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway; Department of Medicine, Haukeland University Hospital, 5009 Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden (författare)
  • Bensing, SophieDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, Sweden (författare)
  • Department of Medicine, Örebro University Hospital, 701 85 Örebro, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, SwedenDepartment of Clinical Science, University of Bergen, 5021 Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, 7804 Bergen, Norway (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Medicine: MDPI12:102077-0383

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