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- Harms-Ringdahl, MatsStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi (författare)
Tomato juice intake suppressed serum concentration of 8-oxodG after extensive physical activity
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
- 2012-05-02
- Springer Science and Business Media LLC,2012
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:su-79934
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-79934URI
- https://doi.org/10.1186/1475-2891-11-29DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- Background: DNA is constantly exposed to reactive oxygen species (ROS), spontaneously arising during the normal oxygen metabolism. ROS may result in temporary as well as permanent modifications in various cellular components such as lipids, proteins and DNA, which may have deleterious consequences. Demonstrating that a dietary supplementation of antioxidants can reduce oxidative DNA damage may provide evidence for the value of such supplementation in prevention of cancer and age related diseases. Findings: The present study was conducted to address whether tomato juice protects against ROS induced by extensive physical exercise in untrained individuals. As a marker of oxidative stress, serum levels of 8-oxodG were monitored using a modified ELISA. An intervention was performed involving 15 untrained healthy subjects who performed a 20 min physical exercise at 80% of maximum pulse using an ergometer bicycle. Blood samples were taken before and one hour after the exercise. The procedure was repeated after 5 weeks with a daily intake of 150 ml tomato juice and followed by a 5 weeks wash-out period and another 5 weeks with a daily intake of tomato juice. The results indicated that a daily intake of tomato juice, equal to 15 mg lycopene per day, for 5 weeks significantly reduced the serum levels of 8-oxodG after an extensive physical exercise. Conclusion: These data strongly suggest that tomato juice has a potential antioxidant effect and may reduce the elevated level of ROS induced by oxidative stress.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Klinisk laboratoriemedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Clinical Laboratory Medicine hsv//eng
- Reactive oxygen species
- ROS
- Free radicals
- Exercise
- Lycopene
- Tomato juice
- Life style
- ELISA
- hMTH1
- 8-oxo-dG
- genetik
- Genetics
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Jenssen, DagStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi(Swepub:su)jenss (författare)
- Haghdoost, SiamakStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi(Swepub:su)shagh (författare)
- Stockholms universitetInstitutionen för genetik, mikrobiologi och toxikologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Nutrition Journal: Springer Science and Business Media LLC11, s. 29-1475-2891
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