SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Kanar Alkass)
 

Search: WFRF:(Kanar Alkass) > Evidence for Cardio...

Evidence for Cardiomyocyte Renewal in Humans

Bergmann, Olaf (author)
Karolinska Institutet
Bhardwaj, Ratan D. (author)
Bernard, Samuel (author)
show more...
Zdunek, Sofia (author)
Barnabe-Heider, Fanie (author)
Karolinska Institutet
Walsh, Stuart (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
Zupicich, Joel (author)
Alkass, Kanar (author)
Karolinska Institutet
Buchholz, Bruce A. (author)
Druid, Henrik (author)
Karolinska Institutet
Jovinge, Stefan (author)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
Frisen, Jonas (author)
Karolinska Institutet
show less...
 (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2009
2009
English.
In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 324:5923, s. 98-102
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

  • Science (Search for host publication in LIBRIS)

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view