Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies

Goldin, Lynn R. (author)

Koshiol, Jill (author)

Turesson, Ingemar (author): Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine

(creator_code:org_t)

2009-07-07
2009
English.
In: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 94:11, s. 1581-1589

Related links:: http://dx.doi.org/10...; show more...; https://doi.org/10.3...; https://lup.lub.lu.s...; https://doi.org/10.3...; http://kipublication...; show less...

Abstract Subject headings

There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.

By the author/editor: Kristinsson, Sig ...; Goldin, Lynn R.; Bjorkholm, Magnu ...; Koshiol, Jill; Turesson, Ingema ...; Landgren, Ola

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

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