WFRF:(Lanekoff Ingela 1975)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03617naa a2200409 4500 | |
| 001 | oai:DiVA.org:uu-347672 | |
| 003 | SwePub | |
| 008 | 180405s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3476722 URI |
| 024 | 7 | a https://doi.org/10.1007/s00216-019-01721-52 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bergman, Hilde-Marleneu Uppsala universitet,Analytisk kemi4 aut0 (Swepub:uu)hilbe345 |
| 245 | 1 0 | a Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging |
| 264 | c 2019-03-20 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Title in dissertation list of papers: Metabolite aberrations at early onset of diabetes detected in rat kidney using mass spectrometry imaging | |
| 520 | a Diabetic kidney disease is a serious complication of diabetes that can ultimately lead to end-stage renal disease. The pathogenesis of diabetic kidney disease is complex, and fundamental research is still required to provide a better understanding of the driving forces behind it. We report regional metabolic aberrations from an untargeted mass spectrometry imaging study of kidney tissue using an insulinopenic rat model of diabetes. Diabetes was induced by intravenous injection of streptozotocin, and kidneys were harvested 2weeks thereafter. Imaging was performed using nanospray desorption electrospray ionization connected to a high-mass-resolving mass spectrometer. No histopathological changes were observed in the kidney sections; however, mass spectrometry imaging revealed a significant increase in several 18-carbon unsaturated non-esterified fatty acid species and monoacylglycerols. Notably, these 18-carbon acyl chains were also constituents of several increased diacylglycerol species. In addition, a number of short- and long-chain acylcarnitines were found to be accumulated while several amino acids were depleted. This study presents unique regional metabolic data indicating a dysregulated energy metabolism in renal mitochondria as an early response to streptozotocin-induced type I diabetes. | |
| 650 | 7 | a NATURVETENSKAPx Kemix Analytisk kemi0 (SwePub)104012 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Analytical Chemistry0 (SwePub)104012 hsv//eng |
| 653 | a Kemi med inriktning mot analytisk kemi | |
| 653 | a Chemistry with specialization in Analytical Chemistry | |
| 700 | 1 | a Lindfors, Linau Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)linli100 |
| 700 | 1 | a Palm, Fredrik,d 1973-u Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)fredpalm |
| 700 | 1 | a Kihlberg, Janu Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)janki643 |
| 700 | 1 | a Lanekoff, Ingela,c Assoc. Prof.d 1975-u Uppsala universitet,Analytisk kemi4 aut0 (Swepub:uu)ingla753 |
| 710 | 2 | a Uppsala universitetb Analytisk kemi4 org |
| 773 | 0 | t Analytical and Bioanalytical Chemistryd : Springer Science and Business Media LLCg 411:13, s. 2809-2816q 411:13<2809-2816x 1618-2642x 1618-2650 |
| 856 | 4 | u https://doi.org/10.1007/s00216-019-01721-5y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1195584/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007/s00216-019-01721-5.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-347672 |
| 856 | 4 8 | u https://doi.org/10.1007/s00216-019-01721-5 |
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