Statistical modeling of atrioventricular nodal function during atrial fibrillation : An update

Sandberg, Frida (författare): Lund University,Lunds universitet,Institutionen för elektro- och informationsteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Electrical and Information Technology,Departments at LTH,Faculty of Engineering, LTH

Sornmo, Leif (författare): Lund University,Lunds universitet,Institutionen för elektro- och informationsteknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Electrical and Information Technology,Departments at LTH,Faculty of Engineering, LTH

(creator_code:org_t)

2013
2013
Engelska 5 s.
Ingår i: BIOSIGNALS 2013 - Proceedings of the International Conference on Bio-Inspired Systems and Signal Processing. - 9789898565365 ; , s. 25-29

Abstract Ämnesord

Stäng

This paper introduces a number of advancements of our recently proposed model of atrioventricular (AV) node function during atrial fibrillation (AF). The model is defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing either one of the two AV nodal pathways, the refractory periods of these pathways, and their prolongation. In the updated model, the characterization of AV nodal pathways is made more detailed and the number of pathways is determined by the Bayesian information criterion. The performance is evaluated on ECG data acquired from twenty-five AF patients during rest and head-up tilt test. The results show that the refined AV node model provides significantly better fit than did the original model. During tilt, the AF frequency increased (6.25 ±0.58 Hz vs. 6.32 ±0.61 Hz, p < 0.05, rest vs. tilt) and the prolongation of the refractory periods decreased for both pathways (slow pathway: 0.23 ±0.20 s vs. 0.11 ±0.10 s, p < 0.001, rest vs. tilt; fast pathway: 0.24±0.31 s vs. 0.16±0.19 s, p < 0.05, rest vs. tilt). These results show that AV node characteristics can be assessed noninvasively for the purpose of quantifying changes induced by autonomic stimulation.

Av författaren/redakt...: Corino, Valentin ...; Sandberg, Frida; Lombardi, Federi ...; Mainardi, Luca T ...; Sornmo, Leif

Om ämnet

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