WFRF:(Marzetti Emanuele)
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LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03874naa a2200505 4500 | |
| 001 | oai:DiVA.org:su-193814 | |
| 003 | SwePub | |
| 008 | 210608s2021 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:146185927 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1938142 URI |
| 024 | 7 | a https://doi.org/10.3390/cells100305372 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1461859272 URI |
| 040 | a (SwePub)sud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Picca, Annau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Italy4 aut |
| 245 | 1 0 | a Cell Death and Inflammation :b The Role of Mitochondria in Health and Disease |
| 264 | c 2021-03-03 | |
| 264 | 1 | b MDPI AG,c 2021 |
| 338 | a print2 rdacarrier | |
| 520 | a Mitochondria serve as a hub for a multitude of vital cellular processes. To ensure an efficient deployment of mitochondrial tasks, organelle homeostasis needs to be preserved. Mitochondrial quality control (MQC) mechanisms (i.e., mitochondrial dynamics, biogenesis, proteostasis, and autophagy) are in place to safeguard organelle integrity and functionality. Defective MQC has been reported in several conditions characterized by chronic low-grade inflammation. In this context, the displacement of mitochondrial components, including mitochondrial DNA (mtDNA), into the extracellular compartment is a possible factor eliciting an innate immune response. The presence of bacterial-like CpG islands in mtDNA makes this molecule recognized as a damaged-associated molecular pattern by the innate immune system. Following cell death-triggering stressors, mtDNA can be released from the cell and ignite inflammation via several pathways. Crosstalk between autophagy and apoptosis has emerged as a pivotal factor for the regulation of mtDNA release, cell’s fate, and inflammation. The repression of mtDNA-mediated interferon production, a powerful driver of immunological cell death, is also regulated by autophagy–apoptosis crosstalk. Interferon production during mtDNA-mediated inflammation may be exploited for the elimination of dying cells and their conversion into elements driving anti-tumor immunity. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a apoptosis | |
| 653 | a damage-associated molecular patterns (DAMPs) | |
| 653 | a immunogenic cell death | |
| 653 | a innate immunity | |
| 653 | a mitochondrial dysfunction | |
| 653 | a mitophagy | |
| 653 | a mitochondrial dynamics | |
| 653 | a mitochondrial quality control (MQC) | |
| 653 | a oxidative stress | |
| 653 | a reactive oxygen species (ROS) | |
| 700 | 1 | a Calvani, Riccardou Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Italy4 aut |
| 700 | 1 | a Coelho-Junior, Hélio José4 aut |
| 700 | 1 | a Marzetti, Emanuele4 aut |
| 710 | 2 | a Stockholms universitetb Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 org |
| 773 | 0 | t Cellsd : MDPI AGg 10:3q 10:3x 2073-4409 |
| 856 | 4 | u https://doi.org/10.3390/cells10030537y Fulltext |
| 856 | 4 | u https://www.mdpi.com/2073-4409/10/3/537/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-193814 |
| 856 | 4 8 | u https://doi.org/10.3390/cells10030537 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146185927 |
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