Sökning: WFRF:(Nalvarte Ivan) > Fluoxetine Affects ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04902naa a2200505 4500 | |
001 | oai:DiVA.org:oru-83056 | |
003 | SwePub | |
008 | 200612s2018 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:su-161025 | |
009 | oai:prod.swepub.kib.ki.se:139236444 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-830562 URI |
024 | 7 | a https://doi.org/10.1124/mol.118.1123422 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1610252 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1392364442 URI |
040 | a (SwePub)orud (SwePub)sud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lupu, Dianau Department of Toxicology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Unit Toxicol Sci, Karolinska Institute, Södertälje, Sweden4 aut |
245 | 1 0 | a Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro |
264 | c 2018-08-16 | |
264 | 1 | a New York :b American Society for Pharmacology and Experimental Therapeutics,c 2018 |
338 | a print2 rdacarrier | |
500 | a Ytterligare forskningsfinansiär: Emil and Wera Cornell's research foundation | |
520 | a Recent meta-analyses found an association between prenatal exposure to the antidepressant fluoxetine (FLX) and an increased risk of autism in children. This developmental disorder has been related to dysfunctions in the brains' rewards circuitry, which, in turn, has been linked to dysfunctions in dopaminergic (DA) signaling. The present study investigated if FLX affects processes involved in dopaminergic neuronal differentiation. Mouse neuronal precursors were differentiated into midbrain dopaminergic precursor cells (mDPCs) and concomitantly exposed to clinically relevant doses of FLX. Subsequently, dopaminergic precursors were evaluated for expression of differentiation and stemness markers using quantitative polymerase chain reaction. FLX treatment led to increases in early regional specification markers orthodenticle homeobox 2 (Otx2) and homeobox engrailed-1 and -2 (En1 and En2). On the other hand, two transcription factors essential for midbrain dopaminergic (mDA) neurogenesis, LIM homeobox transcription factor 1 alpha (Lmx1a) and paired-like homeodomain transcription factor 3 (Pitx3) were downregulated by FLX treatment. The stemness marker nestin (Nes) was increased, whereas the neuronal differentiation marker beta 3-tubulin (Tubb3) decreased. Additionally, we observed that FLX modulates the expression of several genes associated with autism spectrum disorder and downregulates the estrogen receptors (ERs) alpha and beta. Further investigations using ER beta knockout (BERKO) mDPCs showed that FLX had no or even opposite effects on several of the genes analyzed. These findings suggest that FLX affects differentiation of the dopaminergic system by increasing production of dopaminergic precursors, yet decreasing their maturation, partly via interference with the estrogen system. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskap0 (SwePub)1022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Computer and Information Sciences0 (SwePub)1022 hsv//eng |
700 | 1 | a Varshney, Mukesh K.u Karolinska Institutet4 aut |
700 | 1 | a Mucs, Danielu Karolinska Institutet4 aut |
700 | 1 | a Inzunza, Joseu Karolinska Institutet4 aut |
700 | 1 | a Norinder, Ulf,d 1956-u Stockholms universitet,Institutionen för data- och systemvetenskap,Swetox, Karolinska Institutet, Sweden4 aut0 (Swepub:su)unori |
700 | 1 | a Loghin, Feliciau Department of Toxicology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania4 aut |
700 | 1 | a Nalvarte, Ivanu Karolinska Institutet4 aut |
700 | 1 | a Ruegg, Joelleu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Department of Toxicology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Unit Toxicol Sci, Karolinska Institute, Södertälje, Sweden4 org |
773 | 0 | t Molecular Pharmacologyd New York : American Society for Pharmacology and Experimental Therapeuticsg 94:4, s. 1220-1231q 94:4<1220-1231x 0026-895Xx 1521-0111 |
856 | 4 | u https://doi.org/10.1124/mol.118.112342y Fulltext |
856 | 4 | u https://molpharm.aspetjournals.org/content/molpharm/94/4/1220.full.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83056 |
856 | 4 8 | u https://doi.org/10.1124/mol.118.112342 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-161025 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139236444 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy