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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006993naa a2200781 4500
001oai:DiVA.org:uu-425905
003SwePub
008201124s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:kth-286228
009oai:prod.swepub.kib.ki.se:145086093
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4259052 URI
0247 a https://doi.org/10.7554/eLife.552122 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2862282 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1450860932 URI
040 a (SwePub)uud (SwePub)kthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Xie, Mengu Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.4 aut
2451 0a Secondary ossification center induces and protects growth plate structure
264 1b ELIFE SCIENCES PUBLICATIONS LTD,c 2020
338 a electronic2 rdacarrier
500 a QC 20201125
520 a Growth plate and articular cartilage constitute a single anatomical entity early in development but later separate into two distinct structures by the secondary ossification center (SOC). The reason for such separation remains unknown. We found that evolutionarily SOC appears in animals conquering the land - amniotes. Analysis of the ossification pattern in mammals with specialized extremities (whales, bats, jerboa) revealed that SOC development correlates with the extent of mechanical loads. Mathematical modeling revealed that SOC reduces mechanical stress within the growth plate. Functional experiments revealed the high vulnerability of hypertrophic chondrocytes to mechanical stress and showed that SOC protects these cells from apoptosis caused by extensive loading. Atomic force microscopy showed that hypertrophic chondrocytes are the least mechanically stiff cells within the growth plate. Altogether, these findings suggest that SOC has evolved to protect the hypertrophic chondrocytes from the high mechanical stress encountered in the terrestrial environment.
650 7a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Gol'din, Pavelu NAS, Dept Evolutionary Morphol, Schmalhausen Inst Zool, Kiev, Ukraine.4 aut
7001 a Herdina, Anna Neleu Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Med Univ Vienna, Div Anat, MIC, Vienna, Austria.4 aut
7001 a Lopez, Jordi Estefau Uppsala universitet,Evolution och utvecklingsbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)jores915
7001 a Medvedeva, Ekaterina V.u Sechenov Univ, Inst Regenerat Med, Moscow, Russia.4 aut
7001 a Li, Leiu Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.,Univ Calif San Diego, Div Biol Sci, San Diego, CA 92103 USA.4 aut
7001 a Newton, Phillip T.u Karolinska Institutet4 aut
7001 a Kotova, Svetlanau Sechenov Univ, Inst Regenerat Med, Moscow, Russia.;Semenov Inst Chem Phys, Moscow, Russia.4 aut
7001 a Shavkuta, Borisu Sechenov Univ, Inst Regenerat Med, Moscow, Russia.4 aut
7001 a Saxena, Adityau Karolinska Institutet4 aut
7001 a Shumate, Lauren T.u Massachusetts Gen Hosp, Dept Med, Endocrine Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
7001 a Metscher, Brian D.u Univ Vienna, Dept Theoret Biol, Vienna, Austria.4 aut
7001 a Grossschmidt, Karlu Med Univ Vienna, Ctr Anat & Cell Biol, Bone & Biomat Res, Vienna, Austria.4 aut
7001 a Nishimori, Shigekiu Harvard Med Sch, Boston, MA 02115 USA.4 aut
7001 a Akovantseva, Anastasiau Karolinska Institutet4 aut
7001 a Usanova, Anna P.u Sechenov Univ, Inst Regenerat Med, Moscow, Russia.4 aut
7001 a Kurenkova, Anastasiia D.u Sechenov Univ, Inst Regenerat Med, Moscow, Russia.4 aut
7001 a Kumar, Anoopu Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden.4 aut
7001 a Linares Arregui, Ireneu KTH,Hållfasthetslära,KTH Royal Inst Technol, Dept Solid Mech, Stockholm, Sweden.4 aut0 (Swepub:kth)u17vqs3d
7001 a Tafforeau, Paulu European Synchrotron Radiat Facil, Grenoble, France.4 aut
7001 a Fried, Kaju Karolinska Institutet4 aut
7001 a Carlstrom, Mattiasu Karolinska Institutet4 aut
7001 a Simon, Andrasu Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden.,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Sechenov Univ, Inst Regenerat Med, Moscow, Russia.4 aut
7001 a Gasser, T. Christianu KTH,Hållfasthetslära,KTH Royal Inst Technol, Dept Solid Mech, Stockholm, Sweden.4 aut0 (Swepub:kth)u1dvxi4s
7001 a Kronenberg, Henry M.u Massachusetts Gen Hosp, Dept Med, Endocrine Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
7001 a Bastepe, Muratu Massachusetts Gen Hosp, Dept Med, Endocrine Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut
7001 a Cooper, Kimberly L.u Univ Calif San Diego, Div Biol Sci, San Diego, CA 92103 USA.4 aut
7001 a Timashev, Peteru Sechenov Univ, Inst Regenerat Med, Moscow, Russia.;Res Ctr Crystallog & Photon, Inst Photon Technol, Moscow, Russia.;Lomonosov Moscow State Univ, Chem Dept, Leninskiye Gory I-3, Moscow, Russia.4 aut
7001 a Sanchez, Sophieu Uppsala universitet,Evolution och utvecklingsbiologi,Science for Life Laboratory, SciLifeLab,European Synchrotron Radiat Facil, Grenoble, France.;Sorbonne Univ, CR2P, MNHN, CNRS,UPMC, Paris, France.4 aut0 (Swepub:uu)sopsa997
7001 a Adameyko, Igoru Karolinska Institutet4 aut
7001 a Eriksson, Anders,d 1953-u KTH,Hållfasthetslära,KTH Royal Inst Technol, Dept Mech, Stockholm, Sweden.4 aut0 (Swepub:kth)u159sga2
7001 a Chagin, Andrei S.u Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Sechenov Univ, Inst Regenerat Med, Moscow, Russia.4 aut
7102 a Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.b NAS, Dept Evolutionary Morphol, Schmalhausen Inst Zool, Kiev, Ukraine.4 org
7730 t eLIFEd : ELIFE SCIENCES PUBLICATIONS LTDg 9q 9x 2050-084X
8564 u https://doi.org/10.7554/eLife.55212y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1503441/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425905
8564 8u https://doi.org/10.7554/eLife.55212
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-286228
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:145086093

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