Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

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Intracellular Drug Concentrations and Transporters : Measurement, Modeling, and Implications for the Liver

Chu, X. (author)

Korzekwa, K. (author)

Elsby, R. (author)

Fenner, K. (author)

Galetin, A. (author)

Lai, Y. (author)

Moss, A. (author)

Nagar, S. (author)

Rosania, G. R. (author)

Bai, J. P. F. (author)

Polli, J. W. (author)

Sugiyama, Y. (author)

Brouwer, K. L. R. (author)

(creator_code:org_t)

2013-04-10
2013
English.
In: Clinical Pharmacology and Therapeutics. - : Springer Science and Business Media LLC. - 0009-9236 .- 1532-6535. ; 94:1, s. 126-141

Related links:: http://deepblue.lib....; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Intracellular concentrations of drugs and metabolites are often important determinants of efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many factors, including physicochemical properties, uptake/efflux transporters, protein binding, organelle sequestration, and metabolism.This white paper highlights determinants of hepatocyte drug/metabolite concentrations and provides an update on model systems, methods, and modeling/simulation approaches used to quantitatively assess hepatocellular concentrations of molecules. The critical scientific gaps and future research directions in this field are discussed.

By the author/editor: Chu, X.; Korzekwa, K.; Elsby, R.; Fenner, K.; Galetin, A.; Lai, Y.; show more...; Matsson, Pär; Moss, A.; Nagar, S.; Rosania, G. R.; Bai, J. P. F.; Polli, J. W.; Sugiyama, Y.; Brouwer, K. L. R ...; show less...

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