WFRF:(Qazi Khaleda Rahman)
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Mesoporous silica particles potentiate antigen-specific T-cell responses
- Kupferschmidt, Natalia (author)
- Qazi, Khaleda Rahman (author)
- Kemi, Cecilia (author)
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- (creator_code:org_t)
- 2014
- 2014
- English.
- In: Nanomedicine. - 1743-5889 .- 1748-6963. ; 9:12, s. 1835-1846
- Journal article (peer-reviewed)
Abstract
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- Aim: To study the adjuvant effect of mesoporous silica particles and their capability of modifying an already existing allergic Th2-like immune response. Materials & methods: The adjuvant effect of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica particles was studied in an antigen-specific ovalbumin (OVA) system in vitro and in vivo. The capacity of the OVA-loaded SBA-15 particles (SBA-15-OVA) to modify an existing immune response was assessed in a murine allergy model. Results: SBA-15-OVA induced significantly stronger OVA-specific splenocyte proliferation compared with OVA alone. Significantly higher IFN-gamma production was observed in ex vivo OVA-stimulated splenocytes from SBA-15-OVA-immunized mice compared with mice injected with only SBA-15 or OVA. Treatment of OVA-sensitized mice with SBA-15-OVA modified the immune response with significantly lower serum levels of OVA-specific IgE and higher IgG levels compared with the alum-OVA-treated group. Conclusion: The results are promising for the continued development of mesoporous silica materials for therapeutic applications.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Keyword
- adjuvant
- allergy model
- cytokine
- mesoporous silica particle
- ovalbumin
- splenocyte
- T cell
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- ref (subject category)
- art (subject category)
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- Karolinska Institutet
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