Longitudinal changes in Alzheimer's-related plasma biomarkers and brain amyloid

Bilgel, M. (author)

An, Y. (author)

Walker, K. A. (author)

Moghekar, A. R. (author)

Ashton, Nicholas J. (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Kac, Przemyslaw R. (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Karikari, Thomas (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Blennow, Kaj, 1958 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Zetterberg, Henrik, 1973 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Jedynak, B. M. (author)

Thambisetty, M. (author)

Ferrucci, L. (author)

Resnick, S. M. (author)

(creator_code:org_t)

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; https://gup.ub.gu.se...; show less...

Abstract Subject headings

INTRODUCTIONUnderstanding longitudinal plasma biomarker trajectories relative to brain amyloid changes can help devise Alzheimer's progression assessment strategies. METHODSWe examined the temporal order of changes in plasma amyloid-beta ratio (A beta 42/A beta 40${{\rm A}\beta }_{42}/{{\rm A}\beta }_{40}$), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau ratios (p-tau181/A beta 42$\text{p-tau181}/\mathrm{A}{\beta}_{42}$, p-tau231/A beta 42$\text{p-tau231}/\mathrm{A}{\beta}_{42}$) relative to C-11-Pittsburgh compound B (PiB) positron emission tomography (PET) cortical amyloid burden (PiB-/+). Participants (n = 199) were cognitively normal at index visit with a median 6.1-year follow-up. RESULTSPiB groups exhibited different rates of longitudinal change in A beta 42/A beta 40(beta=5.41x10-4,SE=1.95x10-4,p=0.0073)${{\rm A}\beta }_{42}/{{\rm A}\beta }_{40}\ ( {\beta \ = \ 5.41 \times {{10}}<^>{ - 4},{\rm{\ SE\ }} = \ 1.95 \times {{10}}<^>{ - 4},\ p\ = \ 0.0073} )$. Change in brain amyloid correlated with change in GFAP (r = 0.5, 95% CI = [0.26, 0.68]). The greatest relative decline in A beta 42/A beta 40${{\rm A}\beta }_{42}/{{\rm A}\beta }_{40}$ (-1%/year) preceded brain amyloid positivity by 41 years (95% CI = [32, 53]). DISCUSSIONPlasma A beta 42/A beta 40${{\rm A}\beta }_{42}/{{\rm A}\beta }_{40}$ may begin declining decades prior to brain amyloid accumulation, whereas p-tau ratios, GFAP, and NfL increase closer in time.

By the author/editor: Bilgel, M.; An, Y.; Walker, K. A.; Moghekar, A. R.; Ashton, Nicholas ...; Kac, Przemyslaw ...; show more...; Karikari, Thomas; Blennow, Kaj, 19 ...; Zetterberg, Henr ...; Jedynak, B. M.; Thambisetty, M.; Ferrucci, L.; Resnick, S. M.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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