Quantitative T-wave morphology assessment from surface ECG is linked with cardiac events risk in genotype-positive KCNH2 mutation carriers with normal QTc values

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Rosero G) > Quantitative T-wave...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		03960naa a2200385 4500
001		oai:lup.lub.lu.se:8b7d4ce0-a4bc-443b-a22f-fa3ef7dd86ee
003		SwePub
008		191107s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/8b7d4ce0-a4bc-443b-a22f-fa3ef7dd86ee2 URI
024	7	a https://doi.org/10.1111/jce.142102 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Cortez, Danielu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Minnesota Masonic Children's Hospital,University of Minnesota4 aut0 (Swepub:lu)da4478co
245	1 0	a Quantitative T-wave morphology assessment from surface ECG is linked with cardiac events risk in genotype-positive KCNH2 mutation carriers with normal QTc values
264		c 2019-10-16
264	1	b Wiley,c 2019
520		a Introduction: Long QT syndrome (LQTS) mutation carriers have elevated the risk of cardiac events even in the absence of QTc prolongation; however, mutation penetrance in patients with normal QTc may be reflected in abnormal T-wave shape, particularly in KCNH2 mutation carriers. We aimed to assess whether the magnitude of a three-dimensional T-wave vector (TwVM) will identify KCNH2-mutation carriers with normal QTc at risk for cardiac events. Methods: Adult LQT2 patients with QTc < 460 ms in men and <470 ms in women (n = 113, age 42 ± 16 years, 43% male) were compared with genotype-negative family members (n = 1007). The TwVM was calculated using T-wave amplitudes in leads V6, II, and V2 as the square root of (TV62 + TII2 + (0.5*TV2)2). Cox regression analysis adjusted for gender and time-dependent beta-blocker use was performed to assess cardiac event (CE) risk, defined as syncope, aborted cardiac arrest, implantable cardioverter-defibrillator therapy, or sudden death. Results: Dichotomized by median of 0.30 mV, lower TwVM was associated with elevated CE risk compared to those with high TwVM (HR = 2.95, 95% CI, 1.25-6.98, P =.014) and also remained significant after including sex and time-dependent beta-blocker usage in the Cox regression analysis (HR = 2.64, 95% CI, 1.64-4.24, P <.001). However, these associations were found only in women but not in men who had low event rates. Conclusion: T-wave morphology quantified as repolarization vector magnitude using T-wave amplitudes retrieved from standard 12-lead electrocardiogram predicts cardiac events risk in LQT2 women and appears useful for risk stratification of KCNH2-mutation carriers without QTc prolongation.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a cardiac events
653		a long QT syndrome
653		a T-wave vector magnitude
700	1	a Zareba, Wojciechu University of Rochester Medical Center4 aut
700	1	a McNitt, Scottu University of Rochester Medical Center4 aut
700	1	a Polonsky, Bronislavau University of Rochester Medical Center4 aut
700	1	a Rosero, Spencer Z.u University of Rochester Medical Center4 aut
700	1	a Platonov, Pyotr G.u Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)kard-ppl
710	2	a Kardiologib Sektion II4 org
773	0	t Journal of Cardiovascular Electrophysiologyd : Wileyg 30:12, s. 2907-2913q 30:12<2907-2913x 1045-3873x 1540-8167
856	4	u http://dx.doi.org/10.1111/jce.14210y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/8b7d4ce0-a4bc-443b-a22f-fa3ef7dd86ee
856	4 8	u https://doi.org/10.1111/jce.14210

Hitta via bibliotek

Journal of Cardiovascular Electrophysiology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Cortez, Daniel; Zareba, Wojciech; McNitt, Scott; Polonsky, Bronis ...; Rosero, Spencer ...; Platonov, Pyotr ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: Journal of Cardi ...

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se