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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005494naa a2200649 4500
001oai:lup.lub.lu.se:7a7e62eb-52cb-4bba-aa46-daf707b85106
003SwePub
008210903s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/7a7e62eb-52cb-4bba-aa46-daf707b851062 URI
0247 a https://doi.org/10.1186/s40478-021-01225-32 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Wisse, L. E.M.u Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Pennsylvania4 aut0 (Swepub:lu)la3343wi
2451 0a Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions
264 c 2021-07-21
264 1b Springer Science and Business Media LLC,c 2021
520 a The medial temporal lobe (MTL) is a nidus for neurodegenerative pathologies and therefore an important region in which to study polypathology. We investigated associations between neurodegenerative pathologies and the thickness of different MTL subregions measured using high-resolution post-mortem MRI. Tau, TAR DNA-binding protein 43 (TDP-43), amyloid-β and α-synuclein pathology were rated on a scale of 0 (absent)—3 (severe) in the hippocampus and entorhinal cortex (ERC) of 58 individuals with and without neurodegenerative diseases (median age 75.0 years, 60.3% male). Thickness measurements in ERC, Brodmann Area (BA) 35 and 36, parahippocampal cortex, subiculum, cornu ammonis (CA)1 and the stratum radiatum lacunosum moleculare (SRLM) were derived from 0.2 × 0.2 × 0.2 mm3 post-mortem MRI scans of excised MTL specimens from the contralateral hemisphere using a semi-automated approach. Spearman’s rank correlations were performed between neurodegenerative pathologies and thickness, correcting for age, sex and hemisphere, including all four proteinopathies in the model. We found significant associations of (1) TDP-43 with thickness in all subregions (r = − 0.27 to r = − 0.46), and (2) tau with BA35 (r = − 0.31) and SRLM thickness (r = − 0.33). In amyloid-β and TDP-43 negative cases, we found strong significant associations of tau with ERC (r = − 0.40), BA35 (r = − 0.55), subiculum (r = − 0.42) and CA1 thickness (r = − 0.47). This unique dataset shows widespread MTL atrophy in relation to TDP-43 pathology and atrophy in regions affected early in Braak stageing and tau pathology. Moreover, the strong association of tau with thickness in early Braak regions in the absence of amyloid-β suggests a role of Primary Age-Related Tauopathy in neurodegeneration.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Ravikumar, S.u University of Pennsylvania4 aut
7001 a Ittyerah, R.u University of Pennsylvania4 aut
7001 a Lim, S.u University of Pennsylvania4 aut
7001 a Lane, J.u University of Pennsylvania4 aut
7001 a Bedard, M. L.u University of North Carolina4 aut
7001 a Xie, L.u University of Pennsylvania4 aut
7001 a Das, S. R.u University of Pennsylvania4 aut
7001 a Schuck, T.u University of Pennsylvania4 aut
7001 a Grossman, M.u University of Pennsylvania4 aut
7001 a Lee, E. B.u University of Pennsylvania4 aut
7001 a Tisdall, M. D.u University of Pennsylvania4 aut
7001 a Prabhakaran, K.u University of Pennsylvania4 aut
7001 a Detre, J. A.u University of Pennsylvania4 aut
7001 a Mizsei, G.u University of Pennsylvania4 aut
7001 a Trojanowski, J. Q.u University of Pennsylvania4 aut
7001 a Artacho-Pérula, E.u University of Castilla La Mancha4 aut
7001 a de Iñiguez de Onzono Martin, M. M.u University of Castilla La Mancha4 aut
7001 a M. Arroyo-Jiménez, M.u University of Castilla La Mancha4 aut
7001 a Muñoz Lopez, M.u University of Castilla La Mancha4 aut
7001 a Molina Romero, F. J.u University of Castilla La Mancha4 aut
7001 a P. Marcos Rabal, M.u University of Castilla La Mancha4 aut
7001 a Cebada Sánchez, S.u University of Castilla La Mancha4 aut
7001 a Delgado González, J. C.u University of Castilla La Mancha4 aut
7001 a de la Rosa Prieto, C.u University of Castilla La Mancha4 aut
7001 a Córcoles Parada, M.u University of Castilla La Mancha4 aut
7001 a Wolk, D. A.u University of Pennsylvania4 aut
7001 a Irwin, D. J.u University of Pennsylvania4 aut
7001 a Insausti, R.u University of Castilla La Mancha4 aut
7001 a Yushkevich, P. A.u University of Pennsylvania4 aut
7102 a Diagnostisk radiologi, Lundb Sektion V4 org
7730 t Acta Neuropathologica Communicationsd : Springer Science and Business Media LLCg 9:1q 9:1x 2051-5960
8564 u http://dx.doi.org/10.1186/s40478-021-01225-3x freey FULLTEXT
8564 u https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-021-01225-3
8564 8u https://lup.lub.lu.se/record/7a7e62eb-52cb-4bba-aa46-daf707b85106
8564 8u https://doi.org/10.1186/s40478-021-01225-3

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