WFRF:(Simonelli A.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03719naa a2200781 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:236482967 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2364829672 URI |
| 024 | 7 | a https://doi.org/10.1101/2022.11.24.5159322 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bianchini, F4 aut |
| 245 | 1 0 | a Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2 |
| 264 | 1 | b Cold Spring Harbor Laboratory,c 2022 |
| 520 | a Emergence of SARS-CoV-2 variants diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens resilient to viral evolution is therefore necessary. Using coldspot-guided antibody discovery, a screening approach that focuses on portions of the virus spike that are both functionally relevant and averse to change, we identified human neutralizing antibodies to highly conserved viral epitopes. Antibody fp.006 binds the fusion peptide and cross-reacts against coronaviruses of the fourgenera, including the nine human coronaviruses, through recognition of a conserved motif that includes the S2’ site of proteolytic cleavage. Antibody hr2.016 targets the stem helix and neutralizes SARS-CoV-2 variants. Antibody sd1.040 binds to subdomain 1, synergizes with antibody rbd.042 for neutralization and, like fp.006 and hr2.016, protects mice when present as bispecific antibody. Thus, coldspot-guided antibody discovery reveals donor-derived neutralizing antibodies that are cross-reactive withOrthocoronavirinae, including SARS-CoV-2 variants.Broadly cross-reactive antibodies that protect from SARS-CoV-2 variants are revealed by virus coldspot-driven discovery. | |
| 700 | 1 | a Crivelli, V4 aut |
| 700 | 1 | a Abernathy, ME4 aut |
| 700 | 1 | a Guerra, C4 aut |
| 700 | 1 | a Palus, M4 aut |
| 700 | 1 | a Muri, J4 aut |
| 700 | 1 | a Marcotte, Hu Karolinska Institutet4 aut |
| 700 | 1 | a Piralla, A4 aut |
| 700 | 1 | a Pedotti, M4 aut |
| 700 | 1 | a De Gasparo, R4 aut |
| 700 | 1 | a Simonelli, L4 aut |
| 700 | 1 | a Matkovic, M4 aut |
| 700 | 1 | a Toscano, C4 aut |
| 700 | 1 | a Biggiogero, M4 aut |
| 700 | 1 | a Calvaruso, V4 aut |
| 700 | 1 | a Svoboda, P4 aut |
| 700 | 1 | a Rincón, TC4 aut |
| 700 | 1 | a Fava, T4 aut |
| 700 | 1 | a Podešvová, L4 aut |
| 700 | 1 | a Shanbhag, AA4 aut |
| 700 | 1 | a Celoria, A4 aut |
| 700 | 1 | a Sgrignani, J4 aut |
| 700 | 1 | a Stefanik, M4 aut |
| 700 | 1 | a Hönig, V4 aut |
| 700 | 1 | a Pranclova, V4 aut |
| 700 | 1 | a Michalcikova, T4 aut |
| 700 | 1 | a Prochazka, J4 aut |
| 700 | 1 | a Guerrini, G4 aut |
| 700 | 1 | a Mehn, D4 aut |
| 700 | 1 | a Ciabattini, A4 aut |
| 700 | 1 | a Abolhassani, Hu Karolinska Institutet4 aut |
| 700 | 1 | a Jarrossay, D4 aut |
| 700 | 1 | a Uguccioni, M4 aut |
| 700 | 1 | a Medaglini, D4 aut |
| 700 | 1 | a Pan-Hammarström, Q4 aut |
| 700 | 1 | a Calzolai, L4 aut |
| 700 | 1 | a Fernandez, D4 aut |
| 700 | 1 | a Baldanti, F4 aut |
| 700 | 1 | a Franzetti-Pellanda, A4 aut |
| 700 | 1 | a Garzoni, C4 aut |
| 700 | 1 | a Sedlacek, R4 aut |
| 700 | 1 | a Ruzek, D4 aut |
| 700 | 1 | a Varani, L4 aut |
| 700 | 1 | a Cavalli, A4 aut |
| 700 | 1 | a Barnes, CO4 aut |
| 700 | 1 | a Robbiani, DF4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t bioRxiv : the preprint server for biologyd : Cold Spring Harbor Laboratory |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:236482967 |
| 856 | 4 8 | u https://doi.org/10.1101/2022.11.24.515932 |
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- Bianchini, F
- Crivelli, V
- Abernathy, ME
- Guerra, C
- Palus, M
- Muri, J
- visa fler...
- Marcotte, H
- Piralla, A
- Pedotti, M
- De Gasparo, R
- Simonelli, L
- Matkovic, M
- Toscano, C
- Biggiogero, M
- Calvaruso, V
- Svoboda, P
- Rincón, TC
- Fava, T
- Podešvová, L
- Shanbhag, AA
- Celoria, A
- Sgrignani, J
- Stefanik, M
- Hönig, V
- Pranclova, V
- Michalcikova, T
- Prochazka, J
- Guerrini, G
- Mehn, D
- Ciabattini, A
- Abolhassani, H
- Jarrossay, D
- Uguccioni, M
- Medaglini, D
- Pan-Hammarström, ...
- Calzolai, L
- Fernandez, D
- Baldanti, F
- Franzetti-Pellan ...
- Garzoni, C
- Sedlacek, R
- Ruzek, D
- Varani, L
- Cavalli, A
- Barnes, CO
- Robbiani, DF
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