WFRF:(Tollet Egnell P)
Sökning: WFRF:(Tollet Egnell P) > (2000-2004) > Differential clonin...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02983naa a2200445 4500 | |
| 001 | oai:DiVA.org:kth-19928 | |
| 003 | SwePub | |
| 008 | 100810s2000 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-199282 URI |
| 024 | 7 | a https://doi.org/10.1210/en.141.3.9102 DOI |
| 040 | a (SwePub)kth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Tollet-Egnell, P.4 aut |
| 245 | 1 0 | a Differential cloning of growth hormone-regulated hepatic transcripts in the aged rat |
| 264 | 1 | c 2000 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20100525 | |
| 520 | a It has been suggested that aging or at least some of its symptoms are related to a physiological decline in GH levels with age. This study was performed to elucidate age-related changes in GH-dependent effects at the level of gene expression. Through the application of complementary DNA representational difference analysis (RDA) we have identified gene products that are reduced during aging in rat liver. The expression of these genes was restored upon GH treatment. Results from reverse Northern and ribonuclease protection analysis confirmed that the RDA products were truly differentially expressed. In addition to well characterized GH-regulated genes, including CYP2C12, CYP2C13, and alpha(2u)-globulin, we demonstrate the differential expression of at least 11 genes previously not known to be under GH control. Several hepatic transcripts encoding enzymes and receptors involved in the metabolism of protein, carbohydrates, and lipids were identified. Other RDA products consisted of transcripts encoding proteins involved in ATP synthesis, detoxification of reactive oxygen species, or immune responses. This list of GH-regulated genes in the old rat may shed further light on the action and mechanism behind the positive effects of GH on, for example, body composition and the immune system that have been observed in different animal and human studies. | |
| 653 | a glutathione-s-transferase | |
| 653 | a d-dopachrome tautomerase | |
| 653 | a migration inhibitory factor | |
| 653 | a mitochondrial atp synthase | |
| 653 | a gh-replacement therapy | |
| 653 | a acetyl-coa carboxylase | |
| 653 | a coenzyme-a carboxylase | |
| 653 | a fatty-acid synthesis | |
| 653 | a gene-expression | |
| 653 | a factor-i | |
| 700 | 1 | a Flores-Morales, A.4 aut |
| 700 | 1 | a Odeberg, Jacobu KTH,Bioteknologi4 aut0 (Swepub:kth)u1e4yljo |
| 700 | 1 | a Lundeberg, Joakimu KTH,Bioteknologi4 aut0 (Swepub:kth)u1qkn9kw |
| 700 | 1 | a Norstedt, G.4 aut |
| 710 | 2 | a KTHb Bioteknologi4 org |
| 773 | 0 | t Endocrinologyg 141:3, s. 910-921q 141:3<910-921x 0013-7227x 1945-7170 |
| 856 | 4 | u https://academic.oup.com/endo/article-pdf/141/3/910/10356498/endo0910.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-19928 |
| 856 | 4 8 | u https://doi.org/10.1210/en.141.3.910 |
Hitta mer i SwePub
- Av författaren/redakt...
- Tollet-Egnell, P ...
- Flores-Morales, ...
- Odeberg, Jacob
- Lundeberg, Joaki ...
- Norstedt, G.
- Artiklar i publikationen
- Endocrinology
- Av lärosätet
- Kungliga Tekniska Högskolan
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
