WFRF:(Trapani D.)
Search: WFRF:(Trapani D.) > Gold Nanoparticles ...
- 7 of 10
- Previous record
- Next record
- To hitlist
Gold Nanoparticles Functionalized with Angiogenin for Wound Care Application
- Cucci, L. M. (author)
- Trapani, G. (author)
-
- Hansson, Örjan, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
- show more...
- La Mendola, D. (author)
- Satriano, C. (author)
- show less...
- (creator_code:org_t)
- 2021-01-14
- 2021
- English.
- In: Nanomaterials. - : MDPI AG. - 2079-4991. ; 11:1
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- In this work, we aimed to develop a hybrid theranostic nano-formulation based on gold nanoparticles (AuNP)-having a known anti-angiogenic character-and the angiogenin (ANG), in order to tune the angiogenesis-related phases involved in the multifaceted process of the wound healing. To this purpose, spherical were surface "decorated" with three variants of the protein, namely, the recombinant (rANG), the wild-type, physiologically present in the human plasma (wtANG) and a new mutant with a cysteine substitution of the serine at the residue 28 (S28CANG). The hybrid biointerface between AuNP and ANG was scrutinized by a multi-technique approach based on dynamic light scattering, spectroscopic (UV-visible, circular dichroism) and microscopic (atomic force and laser scanning confocal) techniques. The analyses of optical features of plasmonic gold nanoparticles allowed for discrimination of different adsorption modes-i.e.; predominant physisorption and/or chemisorption-triggered by the ANG primary sequence. Biophysical experiments with supported lipid bilayers (SLB), an artificial model of cell membrane, were performed by means of quartz crystal microbalance with dissipation monitoring acoustic sensing technique. Cellular experiments on human umbilical vein endothelial cells (HUVEC), in the absence or presence of copper-another co-player of angiogenesis-were carried out to assay the nanotoxicity of the hybrid protein-gold nanoassemblies as well as their effect on cell migration and tubulogenesis. Results pointed to the promising potential of these nanoplatforms, especially the new hybrid Au-S28CANG obtained with the covalent grafting of the mutant on the gold surface, for the modulation of angiogenesis processes in wound care.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- angiogenesis
- nanomaterial
- plasmonics
- nanomedicine
- copper
- endothelial cells
- confocal microscopy
- QCM-D
- AFM
- mutant protein
- Chemistry
- Science & Technology - Other Topics
- Materials Science
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Nanomaterials (Search for host publication in LIBRIS)
To the university's database
- 7 of 10
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Cucci, L. M.
- Trapani, G.
- Hansson, Örjan, ...
- La Mendola, D.
- Satriano, C.
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Chemical Science ...
- Articles in the publication
- Nanomaterials
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
