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  • Ding, Xue BingFirst Affiliated Hospital of Zhengzhou University,Zhengzhou University (författare)

Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-01-18
  • Springer Science and Business Media LLC,2021
  • 8 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:25d491a6-ebd0-4993-8466-ec17233c0ec4
  • https://lup.lub.lu.se/record/25d491a6-ebd0-4993-8466-ec17233c0ec4URI
  • https://doi.org/10.1038/s41591-020-01198-1DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease (PD). However, there is no direct evidence in humans to support this role1–5. In this study, we used dynamic contrast-enhanced magnetic resonance imaging to assess meningeal lymphatic flow in cognitively normal controls and patients with idiopathic PD (iPD) or atypical Parkinsonian (AP) disorders. We found that patients with iPD exhibited significantly reduced flow through the meningeal lymphatic vessels (mLVs) along the superior sagittal sinus and sigmoid sinus, as well as a notable delay in deep cervical lymph node perfusion, compared to patients with AP. There was no significant difference in the size (cross-sectional area) of mLVs in patients with iPD or AP versus controls. In mice injected with α-synuclein (α-syn) preformed fibrils, we showed that the emergence of α-syn pathology was followed by delayed meningeal lymphatic drainage, loss of tight junctions among meningeal lymphatic endothelial cells and increased inflammation of the meninges. Finally, blocking flow through the mLVs in mice treated with α-syn preformed fibrils increased α-syn pathology and exacerbated motor and memory deficits. These results suggest that meningeal lymphatic drainage dysfunction aggravates α-syn pathology and contributes to the progression of PD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Wang, Xin XinFirst Affiliated Hospital of Zhengzhou University,Zhengzhou University (författare)
  • Xia, Dan HaoZhengzhou University,First Affiliated Hospital of Zhengzhou University (författare)
  • Liu, HanFirst Affiliated Hospital of Zhengzhou University,Zhengzhou University (författare)
  • Tian, Hai YanFirst Affiliated Hospital of Zhengzhou University,Zhengzhou University (författare)
  • Fu, YuZhengzhou University,First Affiliated Hospital of Zhengzhou University (författare)
  • Chen, Yong KangZhengzhou University,First Affiliated Hospital of Zhengzhou University (författare)
  • Qin, ChiFirst Affiliated Hospital of Zhengzhou University,Zhengzhou University (författare)
  • Wang, Jiu QiZhengzhou University,First Affiliated Hospital of Zhengzhou University (författare)
  • Xiang, ZhiFirst Affiliated Hospital of Zhengzhou University,Zhengzhou University (författare)
  • Zhang, Zhong XianZhengzhou University (författare)
  • Cao, Qin ChenFirst Affiliated Hospital of Zhengzhou University (författare)
  • Wang, Wei (författare)
  • Li, Jia YiLund University,Lunds universitet,Neural plasticitet och reparation,Forskargrupper vid Lunds universitet,Neural Plasticity and Repair,Lund University Research Groups,China Medical University, Shenyang(Swepub:lu)mphy-jli (författare)
  • Wu, ErxiBaylor Scott and White Hospital,Dell Medical School (författare)
  • Tang, Bei ShaCentral South University, China (författare)
  • Ma, Ming MingZhengzhou University (författare)
  • Teng, Jun FangZhengzhou University,First Affiliated Hospital of Zhengzhou University (författare)
  • Wang, Xue JingZhengzhou University,First Affiliated Hospital of Zhengzhou University (författare)
  • First Affiliated Hospital of Zhengzhou UniversityZhengzhou University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature Medicine: Springer Science and Business Media LLC27:3, s. 411-4181078-89561546-170X

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