WFRF:(Wersäll Peter)
Sökning: WFRF:(Wersäll Peter) > Treatment fractiona...
- Lindblom, EmelyKarolinska Institutet,Stockholms universitet,Fysikum,Stockholm University (författare)
Treatment fractionation for stereotactic radiotherapy of lung tumours: a modelling study of the influence of chronic and acute hypoxia on tumour control probability
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
- 2014
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:su-102721
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102721URI
- https://doi.org/10.1186/1748-717X-9-149DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-88443URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:129393763URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Background: Stereotactic body radiotherapy (SBRT) for non-small-cell lung cancer (NSCLC) has led to promising local control and overall survival for fractionation schemes with increasingly high fractional doses. A point has however been reached where the number of fractions used might be too low to allow efficient local inter-fraction reoxygenation of the hypoxic cells residing in the tumour. It was therefore the purpose of this study to investigate the impact of hypoxia and extreme hypofractionation on the tumour control probability (TCP) from SBRT.Methods: A three-dimensional model of tumour oxygenation able to simulate oxygenation changes on the microscale was used. The TCP was determined for clinically relevant SBRT fractionation schedules of 1, 3 and 5 fractions assuming either static tumour oxygenation or that the oxygenation changes locally between fractions due to fast reoxygenation of acute hypoxia without an overall reduction in chronic hypoxia.Results: For the schedules applying three or five fractions the doses required to achieve satisfying levels of TCP were considerably lower when local oxygenation changes were assumed compared to the case of static oxygenation; a decrease in D50 of 17.7 Gy was observed for a five-fractions schedule applied to a 20% hypoxic tumour when fast reoxygenation was modelled. Assuming local oxygenation changes, the total doses required for a tumor control probability of 50% were of similar size for one, three and five fractions.Conclusions: Although attractive from a practical point of view, extreme hypofractionation using just one single fraction may result in impaired local control of hypoxic tumours, as it eliminates the possibility for any kind of reoxygenation.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Hypoxia
- Hypofractionation
- SBRT
- NSCLC
- Radiation Physics
- radiofysik
- Medical Radiation Physics
- medicinsk strålningsfysik
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Antonovic, LauraStockholms universitet,Fysikum,Stockholm University(Swepub:su)laan9063 (författare)
- Dasu, AlexandruÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Radiofysikavdelningen US(Swepub:liu)aleda92 (författare)
- Lax, IngmarKarolinska University Hospital (författare)
- Wersäll, PeterKarolinska Institutet (författare)
- Toma-Dasu, IulianaStockholms universitet,Fysikum,Karolinska Institutet, Sweden,Stockholm University and Karolinska Institutet(Swepub:su)iuda0736 (författare)
- Stockholms universitetFysikum (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Radiation Oncology91748-717X
Internetlänk
- https://doi.org/10.1186/1748-717X-9-149Fulltext
- http://www.ro-journal.com/content/pdf/1748-717X-9-149.pdfOpen Access PDF (1.6 MB)
- https://liu.diva-portal.org/smash/get/diva2:603886/FULLTEXT01.pdffulltext:print
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102721
- https://doi.org/10.1186/1748-717X-9-149
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-88443
- http://kipublications.ki.se/Default.aspx?queryparsed=id:129393763
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- Lindblom, Emely
- Antonovic, Laura
- Dasu, Alexandru
- Lax, Ingmar
- Wersäll, Peter
- Toma-Dasu, Iulia ...
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