Sökning: WFRF:(White Sue) > A Transcriptome-Wid...
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000 | 09824naa a2202137 4500 | |
001 | oai:DiVA.org:uu-368161 | |
003 | SwePub | |
008 | 181204s2018 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:139155293 | |
009 | oai:lup.lub.lu.se:f5ad9bbb-4e84-4d66-b5a5-fa964353cbb6 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3681612 URI |
024 | 7 | a https://doi.org/10.1158/0008-5472.CAN-18-09512 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1391552932 URI |
024 | 7 | a https://lup.lub.lu.se/record/f5ad9bbb-4e84-4d66-b5a5-fa964353cbb62 URI |
040 | a (SwePub)uud (SwePub)kid (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lu, Yingchangu Vanderbilt University4 aut |
245 | 1 0 | a A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. |
264 | 1 | c 2018 |
338 | a print2 rdacarrier | |
520 | a .AbstractLarge-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal genes underlying these associations remain largely unknown. Here, we performed a transcriptome-wide association study to search for novel genetic loci and plausible causal genes at known GWAS loci. We used RNA sequencing data (68 normal ovarian tissue samples from 68 individuals and 6,124 cross-tissue samples from 369 individuals) and high-density genotyping data from European descendants of the Genotype-Tissue Expression (GTEx V6) project to build ovarian and cross-tissue models of genetically regulated expression using elastic net methods. We evaluated 17,121 genes for their cis-predicted gene expression in relation to EOC risk using summary statistics data from GWAS of 97,898 women, including 29,396 EOC cases. With a Bonferroni-corrected significance level of P < 2.2 × 10−6, we identified 35 genes, including FZD4 at 11q14.2 (Z = 5.08, P = 3.83 × 10−7, the cross-tissue model; 1 Mb away from any GWAS-identified EOC risk variant), a potential novel locus for EOC risk. All other 34 significantly associated genes were located within 1 Mb of known GWAS-identified loci, including 23 genes at 6 loci not previously linked to EOC risk. Upon conditioning on nearby known EOC GWAS-identified variants, the associations for 31 genes disappeared and three genes remained (P < 1.47 × 10−3). These data identify one novel locus (FZD4) and 34 genes at 13 known EOC risk loci associated with EOC risk, providing new insights into EOC carcinogenesis.Significance: Transcriptomic analysis of a large cohort confirms earlier GWAS loci and reveals FZD4 as a novel locus associated with EOC risk. Cancer Res; 78(18); 5419–30. ©2018 AACR. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Beeghly-Fadiel, Alicia4 aut |
700 | 1 | a Wu, Lang4 aut |
700 | 1 | a Guo, Xingyi4 aut |
700 | 1 | a Li, Bingshan4 aut |
700 | 1 | a Schildkraut, Joellen M4 aut |
700 | 1 | a Im, Hae Kyung4 aut |
700 | 1 | a Chen, Yian A4 aut |
700 | 1 | a Permuth, Jennifer B4 aut |
700 | 1 | a Reid, Brett M4 aut |
700 | 1 | a Teer, Jamie K4 aut |
700 | 1 | a Moysich, Kirsten B4 aut |
700 | 1 | a Andrulis, Irene L4 aut |
700 | 1 | a Anton-Culver, Hoda4 aut |
700 | 1 | a Arun, Banu K4 aut |
700 | 1 | a Bandera, Elisa V4 aut |
700 | 1 | a Barkardottir, Rosa B4 aut |
700 | 1 | a Barnes, Daniel R4 aut |
700 | 1 | a Benitez, Javier4 aut |
700 | 1 | a Bjorge, Line4 aut |
700 | 1 | a Brenton, James4 aut |
700 | 1 | a Butzow, Ralf4 aut |
700 | 1 | a Caldes, Trinidad4 aut |
700 | 1 | a Caligo, Maria A4 aut |
700 | 1 | a Campbell, Ian4 aut |
700 | 1 | a Chang-Claude, Jenny4 aut |
700 | 1 | a Claes, Kathleen B M4 aut |
700 | 1 | a Couch, Fergus J4 aut |
700 | 1 | a Cramer, Daniel W4 aut |
700 | 1 | a Daly, Mary B4 aut |
700 | 1 | a deFazio, Anna4 aut |
700 | 1 | a Dennis, Joe4 aut |
700 | 1 | a Diez, Orland4 aut |
700 | 1 | a Domchek, Susan M4 aut |
700 | 1 | a Dörk, Thilo4 aut |
700 | 1 | a Easton, Douglas F4 aut |
700 | 1 | a Eccles, Diana M4 aut |
700 | 1 | a Fasching, Peter A4 aut |
700 | 1 | a Fortner, Renée T4 aut |
700 | 1 | a Fountzilas, George4 aut |
700 | 1 | a Friedman, Eitan4 aut |
700 | 1 | a Ganz, Patricia A4 aut |
700 | 1 | a Garber, Judy4 aut |
700 | 1 | a Giles, Graham G4 aut |
700 | 1 | a Godwin, Andrew K4 aut |
700 | 1 | a Goldgar, David E4 aut |
700 | 1 | a Goodman, Marc T4 aut |
700 | 1 | a Greene, Mark H4 aut |
700 | 1 | a Gronwald, Jacek4 aut |
700 | 1 | a Hamann, Ute4 aut |
700 | 1 | a Heitz, Florian4 aut |
700 | 1 | a Hildebrandt, Michelle A T4 aut |
700 | 1 | a Høgdall, Claus K4 aut |
700 | 1 | a Hollestelle, Antoinette4 aut |
700 | 1 | a Hulick, Peter J4 aut |
700 | 1 | a Huntsman, David G4 aut |
700 | 1 | a Imyanitov, Evgeny N4 aut |
700 | 1 | a Isaacs, Claudine4 aut |
700 | 1 | a Jakubowska, Anna4 aut |
700 | 1 | a James, Paul4 aut |
700 | 1 | a Karlan, Beth Y4 aut |
700 | 1 | a Kelemen, Linda E4 aut |
700 | 1 | a Kiemeney, Lambertus A4 aut |
700 | 1 | a Kjaer, Susanne K4 aut |
700 | 1 | a Kwong, Ava4 aut |
700 | 1 | a Le, Nhu D4 aut |
700 | 1 | a Leslie, Goska4 aut |
700 | 1 | a Lesueur, Fabienne4 aut |
700 | 1 | a Levine, Douglas A4 aut |
700 | 1 | a Mattiello, Amalia4 aut |
700 | 1 | a May, Taymaa4 aut |
700 | 1 | a McGuffog, Lesley4 aut |
700 | 1 | a McNeish, Iain A4 aut |
700 | 1 | a Merritt, Melissa A4 aut |
700 | 1 | a Modugno, Francesmary4 aut |
700 | 1 | a Montagna, Marco4 aut |
700 | 1 | a Neuhausen, Susan L4 aut |
700 | 1 | a Nevanlinna, Heli4 aut |
700 | 1 | a Nielsen, Finn C4 aut |
700 | 1 | a Nikitina-Zake, Liene4 aut |
700 | 1 | a Nussbaum, Robert L4 aut |
700 | 1 | a Offit, Kenneth4 aut |
700 | 1 | a Olah, Edith4 aut |
700 | 1 | a Olopade, Olufunmilayo I4 aut |
700 | 1 | a Olsson, Håkanu Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups4 aut0 (Swepub:lu)onk-hol |
700 | 1 | a Olsson, Håkan4 aut |
700 | 1 | a Osorio, Ana4 aut |
700 | 1 | a Park, Sue K4 aut |
700 | 1 | a Parsons, Michael T4 aut |
700 | 1 | a Peeters, Petra H M4 aut |
700 | 1 | a Pejovic, Tanja4 aut |
700 | 1 | a Peterlongo, Paolo4 aut |
700 | 1 | a Phelan, Catherine M4 aut |
700 | 1 | a Pujana, Miquel Angel4 aut |
700 | 1 | a Ramus, Susan J4 aut |
700 | 1 | a Rennert, Gad4 aut |
700 | 1 | a Risch, Harvey4 aut |
700 | 1 | a Rodriguez, Gustavo C4 aut |
700 | 1 | a Rodríguez-Antona, Cristina4 aut |
700 | 1 | a Romieu, Isabelle4 aut |
700 | 1 | a Rookus, Matti A4 aut |
700 | 1 | a Rossing, Mary Anne4 aut |
700 | 1 | a Rzepecka, Iwona K4 aut |
700 | 1 | a Sandler, Dale P4 aut |
700 | 1 | a Schmutzler, Rita K4 aut |
700 | 1 | a Setiawan, Veronica W4 aut |
700 | 1 | a Sharma, Priyanka4 aut |
700 | 1 | a Sieh, Weiva4 aut |
700 | 1 | a Simard, Jacques4 aut |
700 | 1 | a Singer, Christian F4 aut |
700 | 1 | a Song, Honglin4 aut |
700 | 1 | a Southey, Melissa C4 aut |
700 | 1 | a Spurdle, Amanda B4 aut |
700 | 1 | a Sutphen, Rebecca4 aut |
700 | 1 | a Swerdlow, Anthony J4 aut |
700 | 1 | a Teixeira, Manuel R4 aut |
700 | 1 | a Teo, Soo H4 aut |
700 | 1 | a Thomassen, Mads4 aut |
700 | 1 | a Tischkowitz, Marc4 aut |
700 | 1 | a Toland, Amanda E4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Tung, Nadine4 aut |
700 | 1 | a Tworoger, Shelley S4 aut |
700 | 1 | a van Rensburg, Elizabeth J4 aut |
700 | 1 | a Vanderstichele, Adriaan4 aut |
700 | 1 | a Vega, Ana4 aut |
700 | 1 | a Edwards, Digna Velez4 aut |
700 | 1 | a Webb, Penelope M4 aut |
700 | 1 | a Weitzel, Jeffrey N4 aut |
700 | 1 | a Wentzensen, Nicolas4 aut |
700 | 1 | a White, Emily4 aut |
700 | 1 | a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)alwol516 |
700 | 1 | a Wu, Anna H4 aut |
700 | 1 | a Yannoukakos, Drakoulis4 aut |
700 | 1 | a Zorn, Kristin K4 aut |
700 | 1 | a Gayther, Simon A4 aut |
700 | 1 | a Antoniou, Antonis C4 aut |
700 | 1 | a Berchuck, Andrew4 aut |
700 | 1 | a Goode, Ellen L4 aut |
700 | 1 | a Chenevix-Trench, Georgia4 aut |
700 | 1 | a Sellers, Thomas A4 aut |
700 | 1 | a Pharoah, Paul D P4 aut |
700 | 1 | a Zheng, Wei4 aut |
700 | 1 | a Long, Jirongu Vanderbilt University4 aut |
710 | 2 | a Vanderbilt Universityb Lunds Melanomstudiegrupp4 org |
710 | 2 | a et al. |
773 | 0 | t Cancer Researchg 78:18, s. 5419-5430q 78:18<5419-5430x 0008-5472x 1538-7445 |
856 | 4 | u http://dx.doi.org/10.1158/0008-5472.CAN-18-0951y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368161 |
856 | 4 8 | u https://doi.org/10.1158/0008-5472.CAN-18-0951 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139155293 |
856 | 4 8 | u https://lup.lub.lu.se/record/f5ad9bbb-4e84-4d66-b5a5-fa964353cbb6 |
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