WFRF:(Zhang Hanqing)
Sökning: WFRF:(Zhang Hanqing) > A novel cis-regulat...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03568naa a2200373 4500 | |
| 001 | oai:DiVA.org:uu-493106 | |
| 003 | SwePub | |
| 008 | 230112s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4931062 URI |
| 024 | 7 | a https://doi.org/10.7554/elife.757492 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Leyhr, Jakeu Uppsala universitet,Evolution och utvecklingsbiologi4 aut0 (Swepub:uu)jakle610 |
| 245 | 1 0 | a A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint |
| 264 | c 2022-11-15 | |
| 264 | 1 | b eLife Sciences Publications Ltd,c 2022 |
| 338 | a electronic2 rdacarrier | |
| 520 | a The acquisition of movable jaws was a major event during vertebrate evolution. The role of NK3 homeobox 2 (Nkx3.2) transcription factor in patterning the primary jaw joint of gnathostomes (jawed vertebrates) is well known, however knowledge about its regulatory mechanism is lacking. In this study, we report a proximal enhancer element of Nkx3.2 that is deeply conserved in most gnathostomes but undetectable in the jawless hagfish and lamprey. This enhancer is active in the developing jaw joint region of the zebrafish Danio rerio, and was thus designated as jaw joint regulatory sequence 1 (JRS1). We further show that JRS1 enhancer sequences from a range of gnathostome species, including a chondrichthyan and mammals, have the same activity in the jaw joint as the native zebrafish enhancer, indicating a high degree of functional conservation despite the divergence of cartilaginous and bony fish lineages or the transition of the primary jaw joint into the middle ear of mammals. Finally, we show that deletion of JRS1 from the zebrafish genome using CRISPR/Cas9 results in a significant reduction of early gene expression of nkx3.2 and leads to a transient jaw joint deformation and partial fusion. Emergence of this Nkx3.2 enhancer in early gnathostomes may have contributed to the origin and shaping of the articulating surfaces of vertebrate jaws. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Utvecklingsbiologi0 (SwePub)106142 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Developmental Biology0 (SwePub)106142 hsv//eng |
| 700 | 1 | a Waldmann, Laurau Uppsala universitet,Evolution och utvecklingsbiologi4 aut0 (Swepub:uu)lauwa544 |
| 700 | 1 | a Filipek-Górniok, Beatau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Evolution och utvecklingsbiologi4 aut0 (Swepub:uu)beafi312 |
| 700 | 1 | a Zhang, Hanqingu Uppsala universitet,Bildanalys och människa-datorinteraktion,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)hanzh404 |
| 700 | 1 | a Allalou, Amin,d 1981-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Bildanalys och människa-datorinteraktion,Image Analysis and Human-Computer Interaction4 aut0 (Swepub:uu)amial914 |
| 700 | 1 | a Haitina, Tatjana,c Docent,d 1981-u Uppsala universitet,Evolution och utvecklingsbiologi4 aut0 (Swepub:uu)tahai516 |
| 710 | 2 | a Uppsala universitetb Evolution och utvecklingsbiologi4 org |
| 773 | 0 | t eLIFEd : eLife Sciences Publications Ltdg 11q 11x 2050-084X |
| 856 | 4 | u https://doi.org/10.7554/elife.75749y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1725869/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-493106 |
| 856 | 4 8 | u https://doi.org/10.7554/elife.75749 |
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