WFRF:(Andersson Marie A.)
Sökning: WFRF:(Andersson Marie A.) > DNA methylation pol...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03260naa a2200373 4500 | |
| 001 | oai:lup.lub.lu.se:d2990ca6-5bae-4f6f-bb78-69cbbc3b78a8 | |
| 003 | SwePub | |
| 008 | 160401s2004 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/2735112 URI |
| 024 | 7 | a https://doi.org/10.1074/jbc.M4036182002 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Lund, G4 aut |
| 245 | 1 0 | a DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E |
| 264 | 1 | c 2004 |
| 520 | a The present work investigates the occurrence and significance of aberrant DNA methylation patterns during early stages of atherosclerosis. To this end, we asked whether the genetically atherosclerosis-prone APOEnull mice show any changes in DNA methylation patterns before the appearance of histologically detectable vascular lesion. We exploited a combination of various techniques: DNA fingerprinting, in vitro methyl-accepting assay, 5-methylcytosine quantitation, histone post-translational modification analysis, Southern blotting, and PCR. Our results show that alterations in DNA methylation profiles, including both hyper- and hypomethylation, were present in aortas and PBMC of 4-week-old mutant mice with no detectable atherosclerotic lesion. Sequencing and expression analysis of 60 leukocytic polymorphisms revealed that epigenetic changes involve transcribed genic sequences, as well as repeated interspersed elements. Furthermore, we showed for the first time that atherogenic lipoproteins promote global DNA hypermethylation in a human monocyte cell line. Taken together, our results unequivocally show that alterations in DNA methylation profiles are early markers of atherosclerosis in a mouse model and may play a causative role in atherogenesis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 700 | 1 | a Andersson, Lindau Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups4 aut0 (Swepub:lu)medf-lpe |
| 700 | 1 | a Lauria, M4 aut |
| 700 | 1 | a Lindholm, Marieu Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups4 aut0 (Swepub:lu)medf-mli |
| 700 | 1 | a Fraga, MF4 aut |
| 700 | 1 | a Villar-Garea, A4 aut |
| 700 | 1 | a Ballestar, E4 aut |
| 700 | 1 | a Esteller, M4 aut |
| 700 | 1 | a Zaina, S4 aut |
| 710 | 2 | a Kardiovaskulär forskning - immunitet och aterosklerosb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Journal of Biological Chemistryg 279:28, s. 29147-29154q 279:28<29147-29154x 1083-351X |
| 856 | 4 | u http://dx.doi.org/10.1074/jbc.M403618200x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/273511 |
| 856 | 4 8 | u https://doi.org/10.1074/jbc.M403618200 |
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- Lund, G
- Andersson, Linda
- Lauria, M
- Lindholm, Marie
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