Phenotypes indicating cytolytic properties of Borrelia-specific interferon-? secreting cells in chronic Lyme neuroborreliosis

Ekerfelt, Christina, 1957- (author): Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin

Jarefors, Sara, 1975- (author): Linköpings universitet,Hälsouniversitetet,Klinisk immunologi

Tynngard, N (author)

Hedlund, M (author)

Bergström, S (author)

Forsberg, Pia, 1949- (author): Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Infektionsmedicin,Infektionskliniken i Östergötland

Ernerudh, Jan, 1952- (author): Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin

(creator_code:org_t)

Elsevier BV, 2003
2003
English.
In: Journal of Neuroimmunology. - : Elsevier BV. - 0165-5728 .- 1872-8421. ; 145:1-2, s. 115-126

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

The immuno-pathogenetic mechanisms underlying chronic Lyme neuroborreliosis are mainly unknown. Human Borrelia burgdorferi (Bb) infection is associated with Bb-specific secretion of interferon-? (IFN-?), which may be important for the elimination of Bb, but this may also cause tissue injury. In order to increase the understanding of the pathogenic mechanisms in chronic neuroborreliosis, we investigated which cell types that secrete IFN-?. Blood mononuclear cells from 13 patients with neuroborreliosis and/or acrodermatitis chronicum atrophicans were stimulated with Bb antigen and the phenotypes of the induced IFN-?-secreting cells were analyzed with three different approaches. Cells expressing CD8 or TCR?d, which both have cytolytic properties, were the main phenotypes of IFN-?-secreting cells, indicating that tissue injury in chronic neuroborreliosis may be mediated by cytotoxic cells.

By the author/editor: Ekerfelt, Christ ...; Jarefors, Sara, ...; Tynngard, N; Hedlund, M; Sander, B; Bergström, S; show more...; Forsberg, Pia, 1 ...; Ernerudh, Jan, 1 ...; show less...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.