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Flux regulation thr...
Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast
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- Qin, Ning, 1990 (author)
- Beijing University of Chemical Technology,Chalmers tekniska högskola,Chalmers University of Technology
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- Li, Lingyun (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Beijing University of Chemical Technology
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- Ji, Xu (author)
- Beijing University of Chemical Technology
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- Pereira, Rui, 1986 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Chen, Yu, 1990 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Yin, Shile (author)
- Beijing University of Chemical Technology
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- Li, Chaokun (author)
- Helsingin Yliopisto,University of Helsinki
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- Wan, Xiaozhen (author)
- Beijing University of Chemical Technology
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- Qiu, Danye (author)
- Albert-Ludwigs-Universität Freiburg,University of Freiburg
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Jiang, Junfeng (author)
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- Luo, Hao, 1992 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Zhang, Yueping (author)
- China Agricultural University
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- Dong, Genlai (author)
- Beijing University of Chemical Technology
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- Zhang, Yiming, 1986 (author)
- Beijing University of Chemical Technology,Chalmers tekniska högskola,Chalmers University of Technology
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- Shi, Shuobo, 1981 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Beijing University of Chemical Technology
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- Jessen, Henning J. (author)
- Albert-Ludwigs-Universität Freiburg,University of Freiburg
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Xia, Jianye (author)
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- Chen, Yun, 1978 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Larsson, Christer, 1958 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Tan, Tianwei (author)
- Beijing University of Chemical Technology
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- Liu, Zihe, 1984 (author)
- Beijing University of Chemical Technology,Chalmers tekniska högskola,Chalmers University of Technology
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- Nielsen, Jens B, 1962 (author)
- Beijing University of Chemical Technology,Chalmers tekniska högskola,Chalmers University of Technology,BioInnovation Institute (BII)
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 186:4, s. 748-763.e15
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https://research.cha... (primary) (free)
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https://doi.org/10.1...
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Abstract
Subject headings
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- Although many prokaryotes have glycolysis alternatives, it's considered as the only energy-generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid-glycolysis yeast. Subsequently, we identified an inositol pyrophosphatase encoded by OCA5 that could regulate glycolysis and respiration by adjusting 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate (5-InsP7) levels. 5-InsP7 levels could regulate the expression of genes involved in glycolysis and respiration, representing a global mechanism that could sense ATP levels and regulate central carbon metabolism. The hybrid-glycolysis yeast did not produce ethanol during growth under excess glucose and could produce 2.68 g/L free fatty acids, which is the highest reported production in shake flask of Saccharomyces cerevisiae. This study demonstrated the significance of hybrid-glycolysis yeast and determined Oca5 as an inositol pyrophosphatase controlling the balance between glycolysis and respiration, which may shed light on the role of inositol pyrophosphates in regulating eukaryotic metabolism.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Växtbioteknologi (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Plant Biotechnology (hsv//eng)
Keyword
- Mig1/Hap4 signaling pathway
- free fatty acids
- OCA5
- hybrid-glycolysis yeast
- inositol pyrophosphate
Publication and Content Type
- art (subject category)
- ref (subject category)
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Cell
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To the university's database
- By the author/editor
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Qin, Ning, 1990
-
Li, Lingyun
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Ji, Xu
-
Pereira, Rui, 19 ...
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Chen, Yu, 1990
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Yin, Shile
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show more...
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Li, Chaokun
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Wan, Xiaozhen
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Qiu, Danye
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Jiang, Junfeng
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Luo, Hao, 1992
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Zhang, Yueping
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Dong, Genlai
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Zhang, Yiming, 1 ...
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Shi, Shuobo, 198 ...
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Jessen, Henning ...
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Xia, Jianye
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Chen, Yun, 1978
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Larsson, Christe ...
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Tan, Tianwei
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Liu, Zihe, 1984
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Nielsen, Jens B, ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agricultural Bio ...
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and Plant Biotechnol ...
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Cell
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Chalmers University of Technology