CD83(+)CCR7(-) Dendritic Cells Accumulate in the Subepithelial Dome and Internalize Translocated Escherichia coli HB101 in the Peyers Patches of Heal Crohns Disease

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Andersson Marie A.) > CD83(+)CCR7(-) Dend...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		03889naa a2200385 4500
001		oai:DiVA.org:liu-16424
003		SwePub
008		090123s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-164242 URI
024	7	a https://doi.org/10.2353/ajpath.2009.0802732 DOI
040		a (SwePub)liu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Salim, Sa'adu Linköpings universitet,Kirurgi,Hälsouniversitetet4 aut0 (Swepub:liu)saasa68
245	1 0	a CD83(+)CCR7(-) Dendritic Cells Accumulate in the Subepithelial Dome and Internalize Translocated Escherichia coli HB101 in the Peyers Patches of Heal Crohns Disease
264	1	b Elsevier BV,c 2009
338		a print2 rdacarrier
520		a Recurrent Crohns disease originates with small erosions in the follicle-associated epithelium overlying the Peyers patches. Animal studies have illustrated mucosal immune regulation by dendritic cells located in the subepithelial dome. The aim of this study was to characterize the dendritic cells at this specific site in patients with Crohns disease. Heal tissues were obtained after surgery performed on Crohns patients; ileal samples from noninflammatory bowel disease and ulcerative colitis served as standard and inflammatory controls, respectively. Flow cytometry of isolated intestinal mononuclear cells showed a larger subset of dendritic cells in Crohns samples compared with controls. This finding was corroborated by confocal microscopy, showing enhanced infiltrates of cells positive for the dendritic cell markers, DC-SIGN(+) and CD83(+), in the subepithelial dome. Moreover, the CD83(+) cells in Crohns tissues showed reduced expression of the lymph node migratory receptor, CCR7, possibly contributing to the high numbers of dendritic cells. After exposure to nonpathogenic Escherichia coli in Ussing chambers, dendritic cells in the subepithelial dome of Crohns disease demonstrated increased co-localization with translocated bacteria. Immunohistochemical results revealed that DC-SIGN(+) cells in Crohns tissues were found to express toll-like receptor 4 and produce tumor necrosis factor-a. In conclusion, nonmigrating dendritic cells that accumulate in the subepithelial dome and internalize nonpathogenic bacteria may be important for the onset and perpetuation of mucosal inflammation in Crohns disease.
653		a MEDICINE
653		a MEDICIN
700	1	a Silva, Manuel Au McMaster University4 aut
700	1	a Keita, Åsau Linköpings universitet,Kirurgi,Hälsouniversitetet4 aut0 (Swepub:liu)asave24
700	1	a Larsson, Marieu Linköpings universitet,Molekylär virologi,Hälsouniversitetet4 aut0 (Swepub:liu)marla67
700	1	a Andersson, Peteru Östergötlands Läns Landsting,Linköpings universitet,Kirurgi,Hälsouniversitetet,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala4 aut0 (Swepub:liu)petan52
700	1	a Magnusson, Karl-Ericu Linköpings universitet,Medicinsk mikrobiologi,Hälsouniversitetet4 aut0 (Swepub:liu)karma55
700	1	a Perdue, Mary Hu McMaster University4 aut
700	1	a Söderholm, Johan Du Östergötlands Läns Landsting,Linköpings universitet,Kirurgi,Hälsouniversitetet,Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala4 aut0 (Swepub:liu)sodda63
710	2	a Linköpings universitetb Kirurgi4 org
773	0	t American Journal of Pathologyd : Elsevier BVg 174:1, s. 82-90q 174:1<82-90x 0002-9440x 1525-2191
856	4	u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-52234y Link to Ph.D. Thesis
856	4	u https://europepmc.org/articles/pmc2631321?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16424
856	4 8	u https://doi.org/10.2353/ajpath.2009.080273

Hitta via bibliotek

American Journal of Pathology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Salim, Sa'ad; Silva, Manuel A; Keita, Åsa; Larsson, Marie; Andersson, Peter; Magnusson, Karl- ...; visa fler...; Perdue, Mary H; Söderholm, Johan ...; visa färre...

Artiklar i publikationen: American Journal ...

Av lärosätet: Linköpings universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se