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Hormonal contracept...
Hormonal contraception and cognition: Considering the influence of endogenous ovarian hormones and genes for clinical translation
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- Gravelsins, Laura (författare)
- Univ Toronto, Canada; 100 St George St, Canada
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- Zhao, Sophia (författare)
- Univ Toronto, Canada
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- Einstein, Gillian, 1952- (författare)
- Linköpings universitet,Tema Genus,Filosofiska fakulteten,Univ Toronto, Canada; Rotman Res Inst, Canada
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(creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2023
- 2023
- Engelska.
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Ingår i: Frontiers in Neuroendocrinology. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0091-3022 .- 1095-6808. ; 70
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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visa färre...
Abstract
Ämnesord
Stäng
- Despite the well-known influence of ovarian hormones on the brain and widespread use of hormonal contraception (HC) since the 1960s, our knowledge of HCs cognitive effects remains limited. To date, the cognitive findings have been inconsistent. In order to establish what might make HC studies more consistent, we surveyed the literature on HCs and cognition to determine whether studies considered HC formulation, phase, pharmacokinetics, duration, and gene interactions, and assessed whether oversight of these factors might contribute to variable findings. We found that synthetic HC hormones exert dose-dependent effects, the day of oral contraceptive (Pill) ingestion is critical for understanding cognitive changes, and gene-cognition relationships differ in women taking the Pill likely due to suppressed endogenous hormones. When these factors were overlooked, results were not consistent. We close with recommendations for research more likely to yield consistent findings and be therefore, translatable.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Hormonal contraception; Cognition; Brain; Genes
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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