Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation

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Fältnamn	Indikatorer	Metadata
000		02321naa a2200361 4500
001		oai:DiVA.org:kth-185568
003		SwePub
008		160422s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-1855682 URI
024	7	a https://doi.org/10.1016/j.cbpa.2013.01.0162 DOI
040		a (SwePub)kth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hammer, Stephan C.4 aut
245	1 0	a Squalene hopene cyclases :b highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation
264	1	b Elsevier,c 2013
338		a print2 rdacarrier
500		a QC 20160429
520		a A review. We review here how the inherent promiscuous nature, as well as the evolvability of terpene cyclase enzymes enables new applications in chem. We mainly focus on squalene hopene cyclases, class II triterpene synthases that use a proton-initiated cationic polycyclization cascade to form carbopolycyclic products. We highlight recent findings to demonstrate that these enzymes are capable of activating different functionalities other than the traditional terminal isoprene CC-group as well as being compatible with a wide range of nucleophiles beyond the 'ene-functionality'. Thus, squalene hopene cyclases demonstrate a great potential to be used as a toolbox for general Bronsted acid catalysis.
650	7	a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653		a review squalene hopene cyclase promiscuous evolvable catalyst stereoselectivity
700	1	a Syren, Per-Olofu Universitaet Stuttgart, Germany4 aut0 (Swepub:kth)u1ewlo1g
700	1	a Seitz, Miriam4 aut
700	1	a Nestl, Bettina M.4 aut
700	1	a Hauer, Bernhard4 aut
710	2	a Universitaet Stuttgart, Germany4 org
773	0	t Current opinion in chemical biologyd : Elsevierg 17:2, s. 293-300q 17:2<293-300x 1367-5931x 1879-0402
856	4	u http://www.sciencedirect.com/science/article/pii/S1367593113000215
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-185568
856	4 8	u https://doi.org/10.1016/j.cbpa.2013.01.016

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Av författaren/redakt...: Hammer, Stephan ...; Syren, Per-Olof; Seitz, Miriam; Nestl, Bettina M ...; Hauer, Bernhard

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