L773:1940 5901
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02613naa a2200265 4500 | |
| 001 | oai:slubar.slu.se:67742 | |
| 003 | SwePub | |
| 008 | 240410s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://res.slu.se/id/publ/677422 URI |
| 040 | a (SwePub)slu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Eriksson, Staffanu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB)4 aut0 (Swepub:slu)46947 |
| 245 | 1 0 | a Thymidine kinase 1 is a better prognostic marker than Ki-67 for pT1 adenocarcinoma of the lung |
| 264 | 1 | c 2014 |
| 264 | 1 | b e-Century Publishing,c 2024 |
| 520 | a Objectives: The sensitivity and reliability of the biomarkers thymidine kinase 1 (TK1) and Ki-67 were studied in relation to clinical features and prognosis of survival for pathological-T1 (pT1) lung adenocarcinoma patients. Methods: TK1 and Ki-67 expression was determined in 80 patients with pT1 adenocarcinoma of the lung and in 20 specimens from normal lung tissues, using immunohistochemistry. Results: TK1 was found in most lung tumor cells both in the cytoplasm and the nuclei. The positive labelling index (LI) for total TK1 was significantly higher than that for Ki-67. There was a significant correlation between the LI of total TK1 and lymph node metastasis, degree of tumor invasion and pathologic stages, which was not found for Ki-67. In addition, the overall 5-year survival of patients was statistically significant different between low and high levels of TK1 expression, but not in cases of Ki-67. A multivariate analysis revealed that expression of TK1, lymph node involvement and TNM pathology staging could serve as independent prognostic factors for the disease progression of pT1 lung adenocarcinoma patients. Conclusions: Compared with Ki-67, TK1 is a more reliable proliferation index in pT1 adenocarcinoma of lung, which can evaluate the invasion and the prognosis of tumor. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 710 | 2 | a Sveriges lantbruksuniversitetb Institutionen för anatomi, fysiologi och biokemi4 org |
| 710 | 2 | a Sveriges lantbruksuniversitet |
| 773 | 0 | t International Journal of Clinical and Experimental Medicineg 7, s. 2120-2128q 7<2120-2128x 1940-5901 |
| 856 | 4 8 | u https://res.slu.se/id/publ/67742 |
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