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Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 3: Amprolium

Koutsoumanis, Konstantinos (author)
Allende, Ana (author)
Alvarez-Ordóñez, Avelino (author)
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Bolton, Declan (author)
Bover-Cid, Sara (author)
Chemaly, Marianne (author)
Davies, Robert (author)
De Cesare, Alessandra (author)
Herman, Lieve (author)
Hilbert, Friederike (author)
Lindqvist, Roland (author)
Nauta, Maarten (author)
Ru, Giuseppe (author)
Simmons, Marion (author)
Skandamis, Panagiotis (author)
Suffredini, Elisabetta (author)
Andersson, Dan I. (author)
Bampidis, Vasileios (author)
Bengtsson-Palme, Johan, 1985 (author)
Gothenburg University,Göteborgs universitet,CARe - Centrum för antibiotikaresistensforskning,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Centre for antibiotic resistance research, CARe,Institute of Biomedicine, Department of Infectious Medicine
Bouchard, Damien (author)
Ferran, Aude (author)
Kouba, Maryline (author)
López Puente, Secundino (author)
López-Alonso, Marta (author)
Nielsen, Søren Saxmose (author)
Pechová, Alena (author)
Petkova, Mariana (author)
Girault, Sebastien (author)
Broglia, Alessandro (author)
Guerra, Beatriz (author)
Innocenti, Matteo Lorenzo (author)
Liébana, Ernesto (author)
López-Gálvez, Gloria (author)
Manini, Paola (author)
Stella, Pietro (author)
Peixe, Luisa (author)
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 (creator_code:org_t)
Wiley, 2021
2021
English.
In: EFSA Journal. - : Wiley. - 1831-4732. ; 19:10
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The specific concentrations of amprolium in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC for amprolium, it was not possible to conclude the assessment. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels of amprolium in feed that showed to have an effect on growth promotion/increased yield were reported. The lack of antibacterial activity at clinically relevant concentrations for amprolium suggests that further studies relating to bacterial resistance are not a priority.

Subject headings

LANTBRUKSVETENSKAPER  -- Veterinärmedicin (hsv//swe)
AGRICULTURAL SCIENCES  -- Veterinary Science (hsv//eng)

Keyword

amprolium
antimicrobial resistance
Feed Antimicrobial Resistance Selection Concentration (FARSC)
growth promotion
food-producing animals
subinhibitory concentration
yield increase

Publication and Content Type

ref (subject category)
art (subject category)

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