WFRF:(Chen Zihan)
Sökning: WFRF:(Chen Zihan) > Spider Silk Protein...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07502naa a2200661 4500 | |
| 001 | oai:DiVA.org:kth-343403 | |
| 003 | SwePub | |
| 008 | 240213s2023 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-212398 | |
| 009 | oai:prod.swepub.kib.ki.se:153318103 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3434032 URI |
| 024 | 7 | a https://doi.org/10.1002/smll.2023040312 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2123982 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1533181032 URI |
| 040 | a (SwePub)kthd (SwePub)umud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Qi, Xingmeiu Soochow Univ, Jiangsu Key Lab Infect & Immun, Inst Biol & Med Sci, Suzhou 215123, Peoples R China.,The Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China4 aut |
| 245 | 1 0 | a Spider Silk Protein Forms Amyloid-Like Nanofibrils through a Non-Nucleation-Dependent Polymerization Mechanism (Small 46/2023) |
| 264 | 1 | b Wiley,c 2023 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20240213 | |
| 520 | a Amyloid fibrils—nanoscale fibrillar aggregates with high levels of order—are pathogenic in some today incurable human diseases; however, there are also many physiologically functioning amyloids in nature. The process of amyloid formation is typically nucleation-elongation-dependent, as exemplified by the pathogenic amyloid-β peptide (Aβ) that is associated with Alzheimer's disease. Spider silk, one of the toughest biomaterials, shares characteristics with amyloid. In this study, it is shown that forming amyloid-like nanofibrils is an inherent property preserved by various spider silk proteins (spidroins). Both spidroins and Aβ capped by spidroin N- and C-terminal domains, can assemble into macroscopic spider silk-like fibers that consist of straight nanofibrils parallel to the fiber axis as observed in native spider silk. While Aβ forms amyloid nanofibrils through a nucleation-dependent pathway and exhibits strong cytotoxicity and seeding effects, spidroins spontaneously and rapidly form amyloid-like nanofibrils via a non-nucleation-dependent polymerization pathway that involves lateral packing of fibrils. Spidroin nanofibrils share amyloid-like properties but lack strong cytotoxicity and the ability to self-seed or cross-seed human amyloidogenic peptides. These results suggest that spidroins´ unique primary structures have evolved to allow functional properties of amyloid, and at the same time direct their fibrillization pathways to avoid formation of cytotoxic intermediates. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Strukturbiologi0 (SwePub)106012 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Structural Biology0 (SwePub)106012 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 653 | a cytotoxicity | |
| 653 | a nanofibril | |
| 653 | a non-nucleation-dependent polymerization | |
| 653 | a seeding | |
| 653 | a spidroin | |
| 700 | 1 | a Wang, Yuu Karolinska Inst, Dept Biosci & Nutr, S-14157 Huddinge, Sweden.;Northeast Forestry Univ, Coll Wildlife & Protected Area, Harbin 150040, Peoples R China.,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; College of Wildlife and Protected Area, Northeast Forestry University, Harbin, China4 aut |
| 700 | 1 | a Yu, Hairuiu Soochow Univ, Jiangsu Key Lab Infect & Immun, Inst Biol & Med Sci, Suzhou 215123, Peoples R China.,The Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China4 aut |
| 700 | 1 | a Liu, Ruifangu Soochow Univ, Jiangsu Key Lab Infect & Immun, Inst Biol & Med Sci, Suzhou 215123, Peoples R China.,The Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China4 aut |
| 700 | 1 | a Leppert, Axelu Karolinska Institutet4 aut |
| 700 | 1 | a Zheng, Zihanu Karolinska Inst, Dept Biosci & Nutr, S-14157 Huddinge, Sweden.;Xi An Jiao Tong Univ, Dept Pharmacol, Xian 710061, Shaanxi, Peoples R China.,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; Department of Pharmacology, Xi'an Jiaotong University, Shaanxi, China4 aut |
| 700 | 1 | a Zhong, Xueyingu KTH,Strukturell bioteknik,School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Huddinge, Sweden4 aut0 (Swepub:kth)u169038p |
| 700 | 1 | a Jin, Zhenu Karolinska Inst, Dept Biosci & Nutr, S-14157 Huddinge, Sweden.;Xi An Jiao Tong Univ, Dept Pharmacol, Xian 710061, Shaanxi, Peoples R China.,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; Department of Pharmacology, Xi'an Jiaotong University, Shaanxi, China4 aut |
| 700 | 1 | a Wang, Hanu Soochow Univ, Jiangsu Key Lab Infect & Immun, Inst Biol & Med Sci, Suzhou 215123, Peoples R China.,The Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China4 aut |
| 700 | 1 | a Li, Xiaoliu Chongqing Med Univ, Dept Pharmacol, Coll Pharm, Chongqing 400016, Peoples R China.,Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, China4 aut |
| 700 | 1 | a Wang, Xiuzheu Shanghai Jiao Tong Univ, Dept Neurol, Sch Med, Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China.,Department of Neurology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China4 aut |
| 700 | 1 | a Landreh, Michaelu Karolinska Institutet4 aut |
| 700 | 1 | a Morozova-Roche, Ludmilla A.u Umeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, S-90187 Umeå, Sweden.4 aut0 (Swepub:umu)lumo0001 |
| 700 | 1 | a Johansson, Janu Karolinska Institutet4 aut |
| 700 | 1 | a Xiong, Sidongu Soochow Univ, Jiangsu Key Lab Infect & Immun, Inst Biol & Med Sci, Suzhou 215123, Peoples R China.,The Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China4 aut |
| 700 | 1 | a Iashchishyn, Igoru Umeå universitet,Institutionen för medicinsk kemi och biofysik,Umeå Univ, Dept Med Biochem & Biophys, S-90187 Umeå, Sweden.4 aut0 (Swepub:umu)igia0001 |
| 700 | 1 | a Chen, Gefeiu Karolinska Institutet4 aut |
| 710 | 2 | a Soochow Univ, Jiangsu Key Lab Infect & Immun, Inst Biol & Med Sci, Suzhou 215123, Peoples R China.b The Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China4 org |
| 773 | 0 | t Smalld : Wileyg 19:46q 19:46x 1613-6810x 1613-6829 |
| 856 | 4 | u https://doi.org/10.1002/smll.202304031y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1784762/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-343403 |
| 856 | 4 8 | u https://doi.org/10.1002/smll.202304031 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212398 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:153318103 |
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