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Development and Val...
Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate : A Cross-sectional Analysis of Pooled Data
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- Pottel, Hans (författare)
- KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium,Catholic University of Leuven
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- Björk, Jonas (författare)
- Lund University,Lunds universitet,EPI@LUND,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Courbebaisse, Marie (författare)
- Georges Pompidou European Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Paris Descartes University, INSERM U1151-CNRS UMR8253, Paris, France
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- Couzi, Lionel (författare)
- CHU de Bordeaux, Université de Bordeaux, CNRS-UMR 5164 Immuno ConcEpT, Bordeaux, France,Centre Hospitalier Universitaire de Bordeaux
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- Ebert, Natalie (författare)
- Charité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany,Charité - University Medicine Berlin
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- Eriksen, Björn O. (författare)
- UiT The Arctic University of Norway, Tromsö, Norway
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- Dalton, R. Neil (författare)
- Evelina London Children's Hospital, London, United Kingdom,Evelina London Children's Healthcare
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- Dubourg, Laurence (författare)
- Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France
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- Gaillard, François (författare)
- Assistance Publique Hôpitaux de Paris (AP-HP), Paris, France
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- Garrouste, Cyril (författare)
- Clermont-Ferrand University Hospital, Clermont-Ferrand, France
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- Grubb, Anders (författare)
- Lund University,Lunds universitet,Cystatin C, njursjukdom, amyloidos och antibiotika,Forskargrupper vid Lunds universitet,Cystatin C, renal disease, amyloidosis and antibiotics,Lund University Research Groups,Skåne University Hospital
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- Jacquemont, Lola (författare)
- CHU Nantes, Nantes University, Nantes, France,Nantes University Hospital,University of Nantes
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- Hansson, Magnus (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Kamar, Nassim (författare)
- CHU Rangueil, INSERM U1043, IFR-BMT, University Paul Sabatier, Toulouse, France,Rangueil Hospital
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- Lamb, Edmund J. (författare)
- East Kent Hospitals University NHS Foundation Trust, Canterbury, United Kingdom,Kent and Canterbury Hospital
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- Legendre, Christophe (författare)
- Hôpital Necker, Assistance Publique Hôpitaux de Paris (AP-HP) and Université Paris Descartes, Paris, France,Necker-Enfants Malades Hospital
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- Littmann, Karin (författare)
- Karolinska Institutet,Karolinska Institute
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- Mariat, Christophe (författare)
- Hôpital Nord, CHU de Saint-Etienne, Saint-Etienne, France
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- Melsom, Toralf (författare)
- UiT The Arctic University of Norway, Tromsö, Norway
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- Rostaing, Lionel (författare)
- Hôpital Michallon, CHU Grenoble-Alpes, La Tronche, France,Grenoble University Hospital
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- Rule, Andrew D. (författare)
- Mayo Clinic, Rochester, Minnesota, USA
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- Schaeffner, Elke (författare)
- Charité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany,Charité - University Medicine Berlin
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- Sundin, Per-Ola, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Örebro University, Örebro, Sweden
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- Turner, Stephen (författare)
- Mayo Clinic, Rochester, Minnesota, USA
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- Bökenkamp, Arend (författare)
- Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
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- Berg, Ulla (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Åsling-Monemi, Kajsa (författare)
- Karolinska Institute,Karolinska University Hospital
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- Selistre, Luciano (författare)
- Mestrado em Ciências da Saúde-Universidade Caxias do Sul Foundation CAPES, Caxias do Sul, Brazil,University of Caxias do Sul
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- Åkesson, Anna (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Larsson, Anders (författare)
- Uppsala University,Uppsala universitet,Klinisk kemi,Skåne University Hospital, Lund, Sweden
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- Nyman, Ulf (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups
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- Delanaye, Pierre (författare)
- University of Liège (ULg CHU), CHU Sart Tilman, Liège, Belgium, and Hôpital Universitaire Carémeau, Nîmes, France
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(creator_code:org_t)
- American College of Physicians, 2021
- 2021
- Engelska.
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Ingår i: Annals of Internal Medicine. - : American College of Physicians. - 0003-4819 .- 1539-3704. ; 174:2, s. 183-191
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.7...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The Chronic Kidney Disease in Children Study (CKiD) equation for children and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for adults are recommended serum creatinine (SCr)-based calculations for estimating glomerular filtration rate (GFR). However, these equations, as well as their combination, have limitations, notably the problem of implausible changes in GFR during the transition from adolescence to adulthood and overestimation of GFR in young adults. The full age spectrum (FAS) equation addresses these issues but overestimates GFR when SCr levels are low.OBJECTIVE: To develop and validate a modified FAS SCr-based equation combining design features of the FAS and CKD-EPI equations.DESIGN: Cross-sectional analysis with separate pooled data sets for development and validation.SETTING: = 13) with measured GFR available.PATIENTS: 11 251 participants in 7 studies (development and internal validation data sets) and 8378 participants in 6 studies (external validation data set).MEASUREMENTS: Clearance of an exogenous marker (reference method), SCr level, age, sex, and height were used to develop a new equation to estimate GFR.RESULTS: ] in adults) across the FAS (2 to 90 years) and SCr range (40 to 490 µmol/L [0.45 to 5.54 mg/dL]) and with fewer estimation errors exceeding 30% (6.5% [CI, 3.8% to 9.1%] in children and 3.1% [CI, 2.5% to 3.6%] in adults) compared with the CKiD and CKD-EPI equations.LIMITATION: No Black patients were included.CONCLUSION: The new EKFC equation shows improved accuracy and precision compared with commonly used equations for estimating GFR from SCr levels.PRIMARY FUNDING SOURCE: Swedish Research Council (Vetenskapsrådet).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
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Pottel, Hans
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Björk, Jonas
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Courbebaisse, Ma ...
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Couzi, Lionel
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Ebert, Natalie
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Eriksen, Björn O ...
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Dalton, R. Neil
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Dubourg, Laurenc ...
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Gaillard, Franço ...
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Garrouste, Cyril
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Grubb, Anders
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Jacquemont, Lola
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Hansson, Magnus
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Kamar, Nassim
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Lamb, Edmund J.
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Legendre, Christ ...
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Littmann, Karin
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Mariat, Christop ...
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Melsom, Toralf
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Rostaing, Lionel
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Rule, Andrew D.
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Schaeffner, Elke
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Sundin, Per-Ola, ...
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Turner, Stephen
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Bökenkamp, Arend
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Berg, Ulla
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Åsling-Monemi, K ...
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Selistre, Lucian ...
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Åkesson, Anna
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Larsson, Anders
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Nyman, Ulf
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Delanaye, Pierre
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Annals of Intern ...
- Av lärosätet
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Örebro universitet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet